Yalamanchi Swaytha, Dobs Adrian
Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Curr Opin Urol. 2017 Nov;27(6):525-531. doi: 10.1097/MOU.0000000000000435.
The purpose of this article is to provide an overview of the increasing evidence suggesting that exogenous testosterone therapy is not associated with improvements in cognition or mood. This article is part of a series, in this issue, in which authors are assigned opinion pieces on controversial topics pertaining to testosterone replacement.
Testosterone is increasingly being prescribed. Particularly in the setting of recent data suggestive of possible cardiovascular risk associated with its use; a clear understanding of the domains of health that improve with exogenous testosterone use is important. Data on endogenous and exogenous testosterone with cognition and mood are mixed, likely partly related to methodological differences of type of testosterone, patient population, and dosing.
Overall, available data are not suggestive of a clear benefit of testosterone supplementation in multiple domains of cognition and in mood. Supraphysiologic testosterone has been associated with adverse psychological outcomes, albeit not uniformly in studies.
本文旨在概述越来越多的证据，这些证据表明外源性睾酮治疗与认知或情绪改善无关。本文是本期系列文章的一部分，在该系列中，作者被分配撰写关于睾酮替代相关争议性话题的观点文章。
睾酮的处方量越来越大。特别是在近期有数据表明其使用可能存在心血管风险的情况下；清楚了解外源性睾酮使用后哪些健康领域会得到改善很重要。关于内源性和外源性睾酮与认知和情绪的数据参差不齐，这可能部分与睾酮类型、患者群体和剂量的方法学差异有关。
总体而言，现有数据并不表明补充睾酮在认知和情绪的多个领域有明显益处。超生理水平的睾酮与不良心理结果有关，尽管在研究中并不一致。
