Institute of Biochemistry, Kiel University, Kiel, Germany.
Institute of Psychology, Kiel University, Kiel, Germany.
Placenta. 2017 Sep;57:13-16. doi: 10.1016/j.placenta.2017.05.015. Epub 2017 May 28.
The cytokine interleukin (IL)-11 activates its target cells through binding to the membrane-bound IL-11 receptor (IL-11R). Female mice deficient in IL-11R (Il11ra) are infertile due to a defect in decidualization when the blastocyst implants. We have recently shown that IL-11 can also signal via a soluble IL-11R (trans-signaling). Which IL-11 pathway is required for fertility in mice is unknown. We confirm that female Il11ramice, lacking both classic and trans-signaling, are infertile. In contrast, the selective blockade of IL-11 trans-signaling does not affect fertility in mice. These results show that classic, but not trans-signaling of IL-11, is essential for fertility in mice.
细胞因子白细胞介素 (IL)-11 通过与膜结合的白细胞介素-11 受体 (IL-11R) 结合来激活其靶细胞。当胚泡着床时，缺乏 IL-11R (Il11ra) 的雌性小鼠由于蜕膜化缺陷而不育。我们最近表明，白细胞介素-11 还可以通过可溶性白细胞介素-11R（转导信号）发出信号。哪种白细胞介素-11 途径对小鼠的生育能力是必需的尚不清楚。我们证实，缺乏经典和转导信号的雌性 Il11ra 小鼠不育。相比之下，选择性阻断白细胞介素-11 的转导信号不会影响小鼠的生育能力。这些结果表明，经典的白细胞介素-11 信号转导而非转导信号对小鼠的生育能力至关重要。
