Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
Chongqing Research Institute, Jilin University, Chongqing 401120, China.
Viruses. 2022 Nov 2;14(11):2434. doi: 10.3390/v14112434.
The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only effective against the classic GI strains that were prevalent before 2010, while there is no effective control against the GII variant strains that are currently a global pandemic. In this review, we summarize the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus-host interaction, in an attempt to find the potential virulence factors influencing PEDV pathogenesis. We conclude with the mechanism by which PEDV components antagonize the immune responses of the virus, and the role of host factors in virus infection. Essentially, this review serves as a valuable reference for the development of attenuated virus vaccines and the potential of host factors as antiviral targets for the prevention and control of PEDV infection.
猪流行性腹泻病毒（PEDV）属于冠状病毒科，会导致新生仔猪出现致命性的水样腹泻。PEDV 在全球范围内流行，具有很高的发病率和死亡率，对养猪业构成了巨大威胁。目前开发的疫苗和药物仅对 2010 年之前流行的经典 GI 株有效，而对目前全球流行的 GII 变异株没有有效的控制措施。在这篇综述中，我们总结了 PEDV 生物学的最新进展，包括其传播和起源、结构和功能、进化以及病毒-宿主相互作用，试图寻找影响 PEDV 发病机制的潜在毒力因子。最后，我们总结了 PEDV 成分拮抗病毒免疫反应的机制，以及宿主因子在病毒感染中的作用。总之，这篇综述为减毒活疫苗的开发以及宿主因子作为预防和控制 PEDV 感染的抗病毒靶点提供了有价值的参考。
