孙德尔本斯木橘素A - E，从孙德尔本斯红树林的木果楝中分离出的五种新柠檬苦素。

Sundarbanxylogranins A-E, five new limonoids from the Sundarban Mangrove, Xylocarpus granatum.

作者信息

Dai Yi-Guo, Wu Jun, Padmakumar Krishna Pillai, Shen Li

机构信息

Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China.

Center for Marine Biodiversity, University of Kerala, Kariavattom, Thiruvananthapuram 695581, Kerala, India.

出版信息

Fitoterapia. 2017 Oct;122:85-89. doi: 10.1016/j.fitote.2017.08.013. Epub 2017 Aug 31.

DOI:10.1016/j.fitote.2017.08.013

PMID:28864040

Abstract

Five new limonoids, named sundarbanxylogranins A-E (1-5), were isolated from the seeds of an Indian mangrove, Xylocarpus granatum, collected from mangrove swamps of the Sundarbans, India. The structures of these limonoids were established by HRESIMS and NMR spectroscopic data. Sundarbanxylogranin A (1) is a rare limonoid containing a bicyclo[5.2.1]dec-3-en-8-one scaffold as the ring A/B-fused core; whereas sundarbanxylogranin B (2) is a typical mexicanolide with an 8α, 30α-epoxy ring. Sundarbanxylogranins C-E (3-5), among which the former two possess a 29-OMe group with different orientation, belong to a small group of limonoids containing a C-O-C oxygen bridge. Sundarbanxylogranin B exhibited moderate anti-HIV activity with an IC value of 23.14±1.29μM and a CC value of 78.45±1.69μM, respectively.

摘要

从印度孙德尔本斯红树林采集的印度红树植物木果楝的种子中分离出了五种新的柠檬苦素，命名为孙德尔本木果楝素A - E（1 - 5）。这些柠檬苦素的结构通过高分辨电喷雾电离质谱（HRESIMS）和核磁共振光谱数据确定。孙德尔本木果楝素A（1）是一种罕见的柠檬苦素，其A/B环稠合核心为双环[5.2.1]癸 - 3 - 烯 - 8 - 酮骨架；而孙德尔本木果楝素B（2）是一种典型的墨西哥内酯，带有8α，30α - 环氧环。孙德尔本木果楝素C - E（3 - 5），其中前两者具有不同取向的29 - OMe基团，属于一小类含有C - O - C氧桥的柠檬苦素。孙德尔本木果楝素B表现出中等的抗HIV活性，其IC值为23.14±1.29μM，CC值分别为78.45±1.69μM。