内源性底物在突触体功能中的重要性。

Importance of endogenous substrates in synaptosomal functions.

作者信息

Kálmán M, Csillag A, Hajós F

出版信息

Int J Neurosci. 1987 May;34(1-2):19-26. doi: 10.3109/00207458708985936.

DOI:10.3109/00207458708985936

Abstract

Synaptosomes were found to contain endogenous substrates in sufficient amount to support physiological ion equilibrium and to maintain the resting oxygen consumption rate. Exogenous substrates were required only in functional states which brought about an increase of oxygen consumption only in the presence of a stimulating agent. Succinate increased oxygen consumption even in the resting phase but proved to be incapable of supplying energy for synaptosomal ion transport processes.

摘要

已发现突触体含有足够量的内源性底物，以维持生理离子平衡并保持静息氧消耗率。仅在功能状态下才需要外源性底物，而这种功能状态只有在刺激剂存在时才会导致氧消耗增加。琥珀酸即使在静息阶段也会增加氧消耗，但事实证明它无法为突触体离子转运过程提供能量。