PARP 抑制剂临床应用中的回复突变：众多基因，众多版本。
Reversion Mutations with Clinical Use of PARP Inhibitors: Many Genes, Many Versions.
机构信息
Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Cancer Discov. 2017 Sep;7(9):937-939. doi: 10.1158/2159-8290.CD-17-0734.
PMID:28864639
Abstract
Reversion mutations associated with PARP inhibitor resistance have been identified in tumors with , and as well as and mutations. Multiple different reversion mutations can occur in a single patient, and they can be detected by analysis of circulating cell-free DNA. .
摘要
已经在具有 和 以及 和 突变的肿瘤中鉴定出与 PARP 抑制剂耐药相关的回复突变。单个患者中可发生多种不同的回复突变，并且可以通过分析循环无细胞 DNA 来检测到。
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