危重症幸存者创伤后应激症状预防的早期干预：一项系统评价方案

Early interventions for the prevention of post-traumatic stress symptoms in survivors of critical illness: protocol for a systematic review.

作者信息

Glaspey Lindsey J, Roberts Michael B, Mazzarelli Anthony, Trzeciak Stephen, Roberts Brian W

机构信息

Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA.

Department of Psychiatry, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA.

出版信息

BMJ Open. 2017 Sep 1;7(9):e018270. doi: 10.1136/bmjopen-2017-018270.

DOI:10.1136/bmjopen-2017-018270

PMID:28864709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5588947/

Abstract

INTRODUCTION

Post-traumatic stress disorder (PTSD) is being increasingly reported among survivors of critical illness and injury. Previous work has demonstrated that PTSD reduces patient quality of life and ability to return to work, as well as increases healthcare costs. As such, identifying interventions aimed at preventing the development of critical illness-related PTSD could have an important public health impact. The objective of this systematic review is to collate the world's literature on early interventions aimed at preventing PTSD among survivors of critical illness.

METHODS AND ANALYSIS

We will perform a qualitative systematic review of human clinical trials of interventions aimed at preventing or reducing critical illness-related PTSD symptoms. We will methodically search CENTRAL, MEDLINE, Embase and CINAHL. We will also search websites containing details on clinical trials registration (National Library of Medicine's ClinicalTrials.gov and the WHO's International Clinical Trials Registry Platform), as well as screen reference lists of the articles we select for inclusion to identify additional studies for potential inclusion. Two authors will independently review all search results. After identification and inclusion of articles, we will use a standardised form for data extraction. We will use tables to describe the study type, populations, interventions tested and timing of interventions, outcome measures and effects of interventions on outcome measures compared with control groups. This review will be completed between 1 August 2017 and 31 August 2017.

ETHICS AND DISSEMINATION

The proposed systematic review will not collect individual patient level data and does not require ethical approval. Results of this study will contribute to the understanding of critical illness-related PTSD and help prompt future research aimed at further developing interventions to prevent PTSD symptoms in survivors of critical illness.

PROSPERO REGISTRATION NUMBER

This systematic review is registered in the PROSPERO international prospective register of systematic reviews (registration number CRD42017069672).

摘要

引言

创伤后应激障碍（PTSD）在危重病和受伤幸存者中的报告越来越多。先前的研究表明，PTSD会降低患者的生活质量和重返工作岗位的能力，还会增加医疗费用。因此，确定旨在预防危重病相关PTSD发生的干预措施可能会产生重要的公共卫生影响。本系统评价的目的是整理全球有关旨在预防危重病幸存者发生PTSD的早期干预措施的文献。

方法与分析

我们将对旨在预防或减轻危重病相关PTSD症状的干预措施的人体临床试验进行定性系统评价。我们将系统地检索Cochrane系统评价数据库、医学期刊数据库、荷兰医学文摘数据库和护理学与健康领域数据库。我们还将检索包含临床试验注册详细信息的网站（美国国立医学图书馆的临床试验.gov和世界卫生组织的国际临床试验注册平台），并筛选我们选择纳入的文章的参考文献列表，以识别可能纳入的其他研究。两位作者将独立审查所有检索结果。在识别和纳入文章后，我们将使用标准化表格进行数据提取。我们将使用表格描述研究类型、人群、测试的干预措施和干预时间、结局指标以及与对照组相比干预措施对结局指标的影响。本评价将于2017年8月1日至2017年8月31日完成。