Fazeli Alireza, Holt William V
Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Level 4, Jessop Wing, Tree Root Walk, Sheffield, S10 2SF, UK.
Institute of Biomedicine and Translational Medicine, Department of Pathophysiology, University of Tartu, 14B Ravila, Tartu, 50411, Estonia.
Adv Exp Med Biol. 2017;1014:1-14. doi: 10.1007/978-3-319-62414-3_1.
Definition of the periconception period is not an exact science and is probably somewhat arbitrary. One can define it as spanning the period from the final stages of gamete maturation until formation of the embryo and the stages of embryonic development and implantation. Hence, the periconception period includes periods when spermatozoa are in the female reproductive tract, oocytes are matured and ovulated into the oviduct, fertilization occurs and the embryo undergoes development. By definition the implantation process and the early stages of placenta formation are also regarded as a part of the periconception period. In this article we highlight a few of the major advances which have transformed this topic over the last two decades. It is now clear that the fitness and wellbeing of developing mammalian embryos, including the human, are highly dependent on the health status, diet and habits of both parents especially in the months and weeks that precede the formation of oocytes and spermatozoa.
围孕期的定义并非一门精确的科学,可能在一定程度上具有主观性。人们可以将其定义为从配子成熟的最后阶段一直到胚胎形成以及胚胎发育和着床阶段的这段时期。因此,围孕期包括精子在女性生殖道内、卵母细胞成熟并排卵至输卵管、受精发生以及胚胎进行发育的各个时期。根据定义,着床过程和胎盘形成的早期阶段也被视为围孕期的一部分。在本文中,我们重点介绍过去二十年来改变这一领域的一些重大进展。现在很清楚,包括人类在内的发育中的哺乳动物胚胎的健康和福祉高度依赖于父母双方的健康状况、饮食和习惯,尤其是在卵母细胞和精子形成前的数月和数周内。