载脂蛋白 A5、载脂蛋白 B、载脂蛋白 C3 和 ABCA1 基因多态性对缺血性脑卒中的影响：荟萃分析证据。
The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.
机构信息
Institute of Bioproduct Development and Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81300 Johor, Malaysia.
Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, QLD 4059, Australia.
出版信息
Atherosclerosis. 2017 Oct;265:60-70. doi: 10.1016/j.atherosclerosis.2017.08.003. Epub 2017 Aug 19.
BACKGROUND AND AIMS
Genetic studies have been reported on the association between APOA5, APOB, APOC3 and ABCA1 gene polymorphisms and ischemic stroke, but results remain controversial. Hence, this meta-analysis aimed to infer the causal relationships of APOA5 (rs662799, rs3135506), APOB (rs693, rs1042031, rs1801701), APOC3 (rs4520, rs5128, rs2854116, rs2854117) and ABCA1 rs2230806 with ischemic stroke risk.
METHODS
A systematic review was performed for all the articles retrieved from multiple databases, up until March 2017. Data were extracted from all eligible studies, and meta-analysis was carried out using RevMan 5.3 and R package 3.2.1. The strength of association between each studied polymorphism and ischemic stroke risk was measured as odds ratios (ORs) and 95% confidence intervals (CIs), under fixed- and random-effect models.
RESULTS
A total of 79 studies reporting on the association between the studied polymorphisms and ischemic stroke risk were identified. The pooled data indicated that all genetic models of APOA5 rs662799 (ORs = 1.23-1.43), allelic and over-dominant models of APOA5 rs3135506 (ORs = 1.77-1.97), APOB rs1801701 (ORs = 1.72-2.13) and APOB rs1042031 (ORs = 1.66-1.88) as well as dominant model of ABCA1 rs2230806 (OR = 1.31) were significantly associated with higher risk of ischemic stroke. However, no significant associations were observed between ischemic stroke and the other five polymorphisms, namely ApoB (rs693) and APOC3 (rs4520, rs5128, rs2854116 and rs2854117), under any genetic model.
CONCLUSIONS
The present meta-analysis confirmed a significant association of APOA5 rs662799 CC, APOA5 rs3135506 CG, APOB rs1801701 GA, APOB rs1042031 GA and ABCA1 rs2230806 GG with increased risk of ischemic stroke.
背景与目的
已有研究报道载脂蛋白 A5（APOA5）、载脂蛋白 B（APOB）、载脂蛋白 C3（APOC3）和 ABCA1 基因多态性与缺血性卒中之间的关联，但结果仍存在争议。因此，本荟萃分析旨在推断 APOA5（rs662799、rs3135506）、APOB（rs693、rs1042031、rs1801701）、APOC3（rs4520、rs5128、rs2854116、rs2854117）和 ABCA1 rs2230806 基因多态性与缺血性卒中风险的因果关系。
方法
从多个数据库中检索所有文章，进行系统综述，检索截至 2017 年 3 月。从所有合格研究中提取数据，并使用 RevMan 5.3 和 R 包 3.2.1 进行荟萃分析。使用固定效应模型和随机效应模型，以比值比（ORs）和 95%置信区间（CIs）衡量每个研究多态性与缺血性卒中风险之间的关联强度。
结果
共确定了 79 项研究，报道了所研究的多态性与缺血性卒中风险之间的关系。汇总数据表明，APOA5 rs662799 的所有遗传模型（ORs=1.23-1.43）、APOA5 rs3135506 的等位基因和超显性模型（ORs=1.77-1.97）、APOB rs1801701（ORs=1.72-2.13）和 APOB rs1042031（ORs=1.66-1.88）以及 ABCA1 rs2230806 的显性模型（OR=1.31）与缺血性卒中风险增加显著相关。然而，在任何遗传模型下，与其他五个多态性（APOB（rs693）和 APOC3（rs4520、rs5128、rs2854116 和 rs2854117））之间均未观察到缺血性卒中的显著相关性。
结论
本荟萃分析证实 APOA5 rs662799 CC、APOA5 rs3135506 CG、APOB rs1801701 GA、APOB rs1042031 GA 和 ABCA1 rs2230806 GG 与缺血性卒中风险增加显著相关。
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