Jesus-Ribeiro Joana, Vieira Elsa, Ferreira Pedro, Januário Cristina, Freire António
Neurology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
Centre for Health Studies and Research. Faculdade de Economia. Universidade de Coimbra. Coimbra. Portugal.
Acta Med Port. 2017 May 31;30(5):395-401. doi: 10.20344/amp.8202.
Parkinson's disease has a significant impact in quality of life, which can be assessed with 39-item Parkinson's Disease Questionnaire and Parkinson's Disease Quality of Life Questionnaire. This study aimed to evaluate the reliability and validity of these scales in Portuguese patients.
Reliability was assessed through internal consistency (Cronbach's alpha) and reproducibility (intraclass correlation coefficient). Regarding construct validity, we performed one-way analysis of variance across different groups according to modified Hoehn and Yahr scale. For criterion validity, we compared both scales with each other and with the Short Form 36-item Health Survey.
In a total of 100 patients with Parkinson's disease, Cronbach's alpha ranged for 39-item Parkinson's Disease Questionnaire between 0.66 - 0.98, and for Parkinson's Disease Quality of Life Questionnaire, between 0.78 - 0.98. Intraclass correlation coefficient for 39-item Parkinson's Disease Questionnaire ranged between 0.49 - 0.96, and for Parkinson's Disease Quality of Life Questionnaire, ranged between 0.65 - 0.96. Both scales showed, in general, capacity to discriminate differences among patients in the different stages of disease. The scales presented moderate to strong magnitude correlations with some Short Form 36-item Health Survey domains.
Cronbach's alpha coefficients for most domains were satisfactory. Overall, it has been demonstrated good reproducibility, as well as construct and criterion validity.
The Portuguese versions of both scales showed to be valid and reliable.
帕金森病对生活质量有重大影响，可通过39项帕金森病问卷和帕金森病生活质量问卷进行评估。本研究旨在评估这些量表在葡萄牙患者中的信度和效度。
通过内部一致性（克朗巴哈系数）和可重复性（组内相关系数）评估信度。关于结构效度，我们根据改良的Hoehn和Yahr量表对不同组进行单因素方差分析。对于效标效度，我们将这两个量表相互比较，并与简短36项健康调查进行比较。
在总共100例帕金森病患者中，39项帕金森病问卷的克朗巴哈系数在0.66 - 0.98之间，帕金森病生活质量问卷的克朗巴哈系数在0.78 - 0.98之间。39项帕金森病问卷的组内相关系数在0.49 - 0.96之间，帕金森病生活质量问卷的组内相关系数在0.65 - 0.96之间。总体而言，这两个量表都显示出能够区分疾病不同阶段患者之间的差异。这些量表与简短36项健康调查的一些领域呈现出中度到高度的相关性。
大多领域的克朗巴哈系数令人满意。总体而言，已证明具有良好的可重复性以及结构效度和效标效度。
这两个量表的葡萄牙语版本显示出有效且可靠。
