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胸大肌肌筋膜瓣在挽救性全喉切除术后减少涎瘘中的疗效

Efficacy of the myofascial pectoralis major flap in the reduction of salivary fistulas after salvage total laryngectomy.

作者信息

Chiesa Estomba Carlos Miguel, González García Jose Angel, Sistiaga Suarez Jon Alexander, Thomas Arrizabalaga Izaskun, Larruscain Sarasola Ekhiñe, Altuna Mariezcurrena Xabier

机构信息

Servicio de Otorrinolaringología-Cirugía de Cabeza y Cuello, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.

Servicio de Otorrinolaringología-Cirugía de Cabeza y Cuello, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España.

出版信息

Acta Otorrinolaringol Esp (Engl Ed). 2018 Mar-Apr;69(2):99-104. doi: 10.1016/j.otorri.2017.06.003. Epub 2017 Sep 1.

Abstract

INTRODUCTION

Pharyngocutaneous fistula is the most frequent complication after total laryngectomy. Its incidence varies between 9%-25% in post primary total laryngectomy patients, to 14%-57% in salvage laryngectomy post radiotherapy or post chemotherapy + radiotherapy. The pectoralis major myofascial flap (PMMF)is postulated as a useful tool to decrease the incidence of this complication.

MATERIALS AND METHOD

Retrospective analysis of a group of patients treated by salvage laryngectomy, associated or not with pharyngeal closure reinforcement with PMMF.

RESULTS

Twenty patients were included, 18 males (90%) and 2 females (10%), in 10 of whom the PMMF was used. The average age was 66.65 years. Seventeen (85%) had a laryngeal tumour and 3 (15%) had a hypopharyngeal tumour. Eight (80%) patients in the non-PMMF group had postoperative fistula, whereas only 2 (20%) patients in the PMMF group had a fistula during the postoperative period (P=.005). The mean time for fistula closure was significantly shorter in the cases where PMMF flap was used (16±11 days vs. 76.8±67 days, P=.001), as was hospital stay (19. 6±18 days vs. 83.9±77 days, P=.001).

CONCLUSION

The use of PMMF in our series is associated with a lower rate of post salvage laryngectomy fistulas in patients treated primarily by organ preservation protocol for laryngeal/hypopharyngeal cancer. In turn, it promotes local healing by decreasing the mean duration of fistula closure and the mean hospital stay.

摘要

引言

咽皮肤瘘是全喉切除术后最常见的并发症。其发生率在初次全喉切除术后患者中为9%-25%,在放疗后或化疗+放疗后的挽救性喉切除术后患者中为14%-57%。胸大肌肌筋膜瓣(PMMF)被认为是降低该并发症发生率的有效工具。

材料与方法

对一组接受挽救性喉切除术的患者进行回顾性分析,这些患者是否联合使用PMMF进行咽闭合加强术。

结果

纳入20例患者,其中男性18例(90%),女性2例(10%),10例使用了PMMF。平均年龄为66.65岁。17例(85%)患有喉肿瘤,3例(15%)患有下咽肿瘤。非PMMF组8例(80%)患者术后发生瘘管,而PMMF组仅2例(20%)患者在术后发生瘘管(P=0.005)。使用PMMF瓣的病例中,瘘管闭合的平均时间明显更短(16±11天 vs. 76.8±67天,P=0.001),住院时间也是如此(19.6±18天 vs. 83.9±77天,P=0.001)。

结论

在我们的系列研究中,对于主要采用喉/下咽癌器官保留方案治疗的患者,使用PMMF与挽救性喉切除术后较低的瘘管发生率相关。反过来,它通过缩短瘘管闭合的平均持续时间和平均住院时间促进局部愈合。

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