Touvay C, Vilain B, Sirois P, Soufir M, Braquet P
J Pharm Pharmacol. 1987 Jun;39(6):454-8. doi: 10.1111/j.2042-7158.1987.tb03419.x.
Gossypol, a substance extracted from cotton plants, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4 (LTB4), leukotriene D4 (LTD4) and PAF-acether but not the responses to histamine (except at high concentration). It was slightly less potent than nordihydroguaiaretic acid (NDGA) and a PAF-antagonist (BN 52021). From previously reported effects of gossypol on the cyclooxygenase and lipoxygenases, and on the similarity of the inhibition produced by NDGA and gossypol on the lung parenchyma, it is suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung.
棉酚是从棉花植株中提取的一种物质，它能显著抑制白三烯B4（LTB4）、白三烯D4（LTD4）和血小板活化因子（PAF-乙醚）刺激豚鼠肺实质条的收缩反应，但对组胺刺激的反应（高浓度时除外）无抑制作用。其效力略低于去甲二氢愈创木酸（NDGA）和一种PAF拮抗剂（BN 52021）。根据先前报道的棉酚对环氧化酶和脂氧化酶的作用，以及NDGA和棉酚对肺实质产生的抑制作用的相似性，提示棉酚对肺实质肌性活动的抑制作用是由于其与豚鼠肺内环氧化酶产物的形成相互作用所致。
