Jancar S, Thériault P, Braquet P, Sirois P
Prostaglandins. 1987 Feb;33(2):199-208. doi: 10.1016/0090-6980(87)90006-2.
The myotropic effect of platelet activating factor (PAF), leukotriene D4 (LTD4) and histamine were compared on guinea pig pulmonary tissues. The initial administration of PAF induced a contraction of strips of trachea, bronchus and lung parenchyma. However subsequent injections were characterized by relaxation of trachea and bronchus and a highly reduced (if any) contraction of the parenchyma. The three tissues of the guinea pig respiratory system contracted strongly to leukotriene D4 and histamine. Indomethacin blocked PAF-induced relaxation of the trachea and bronchus and reduced the contraction of the lung parenchyma. The injection of PAF in the pulmonary circulation stimulated the release of substance(s) causing the contraction of the trachea, bronchus and parenchyma. This study suggests that PAF is not a direct agonist of bronchoconstriction.
比较了血小板活化因子（PAF）、白三烯D4（LTD4）和组胺对豚鼠肺组织的亲肌效应。最初给予PAF会引起气管、支气管和肺实质条带收缩。然而，随后的注射表现为气管和支气管松弛，实质收缩高度减弱（若有收缩的话）。豚鼠呼吸系统的这三种组织对白三烯D4和组胺强烈收缩。吲哚美辛可阻断PAF诱导的气管和支气管松弛，并降低肺实质的收缩。在肺循环中注射PAF会刺激引起气管、支气管和实质收缩的物质释放。这项研究表明PAF不是支气管收缩的直接激动剂。
