果胶-6-氨基己酸-磁铁矿纳米粒子的合成与表征及其在药物输送中的应用。
Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery.
机构信息
University School of Basic and Applied Sciences, Guru Gobind Singh Indraprastha University, Sector 16-C, Dwarka, New Delhi 110078, India.
National Physical Laboratory, Dr. K.S. Krishnan Road, New Delhi 110012, India.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:243-251. doi: 10.1016/j.msec.2017.05.097. Epub 2017 May 15.
In this study, we have synthesized magnetic nanocomposites of magnetite nanoparticles coated with 6-aminohexanoic acid and pectin (MAP). The size of the aqueous dispersion of the nanocomposites was 147nm with a Polydispersity index (PDI) of 0.32, and the nanocomposites were stable in NaCl up to a concentration of 0.45% (w/v) after which they aggregated. The dispersion of the nanocomposites was stable in Dulbecco's Modified Eagle's medium (DMEM) in the presence of 5 and 10% fetal bovine serum (FBS). Curcumin was used as a model drug to evaluate the potential of the nanocomposites for drug delivery applications. The release behavior of curcumin from the nanocomposites showed a biphasic pattern with initial burst release followed by a slow release, and the size of the aqueous dispersion of curcumin loaded nanocomposites was 159nm with a PDI of 0.34.
在这项研究中，我们合成了磁性纳米复合材料，其由被 6-氨基己酸和果胶（MAP）涂覆的磁铁矿纳米颗粒组成。纳米复合材料的水分散体的粒径为 147nm，多分散指数（PDI）为 0.32，并且在浓度高达 0.45%（w/v）的 NaCl 下纳米复合材料稳定，之后它们会聚集。在含有 5%和 10%胎牛血清（FBS）的 Dulbecco 改良 Eagle 培养基（DMEM）中，纳米复合材料的分散体稳定。姜黄素被用作模型药物，以评估纳米复合材料在药物传递应用中的潜力。姜黄素从纳米复合材料中的释放行为表现出双相模式，初始突释随后是缓慢释放，并且负载有姜黄素的纳米复合材料的水分散体的粒径为 159nm，PDI 为 0.34。
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