School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210089, PR China.
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210089, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:362-370. doi: 10.1016/j.msec.2017.05.064. Epub 2017 May 11.
Synergistic therapy has caused increasing interest in recent treatment of cancer owing to its preferable therapeutic efficiency to most single antineoplastic protocol. Herein, we design a co-delivery two drugs nanosystem based on biodegradable liposomes, loading cisplatin, Indocyanine green (ICG), and CJM126 coupled with cholesterol derivative (CJM-Chol) for the purpose of synergistic therapy. The obtained nanoparticles showed a uniform diameter of 103.8nm and a favorable morphology. The investigation on near infrared radiated (NIR) responsive release showed that NIR mediated photothermal conversion induced a controllable drug release from liposomes. Furthermore, the designed liposomes (only 50μg/mL) displayed an inspiring photothermal conversion efficiency and received a high temperature (65.6°C, Tm=42°C) when exposed to an 808nm near infrared laser (1.54W, 5min). Besides, it turned out that the delivery system could be efficiently endocytosed by tumor cells, which attributed to its admirable biocompatibility and the targeting role of folate. The prepared nanoparticles showed significantly excellent inhibitory effect (3.05% cell viability in 24h) on MDA-MB-231 cells when added irradiation as compared with free cisplatin (28.41%) or treatment without NIR (11.24%) in our study. Our research highlights the present nanoparticles provide a promising strategy for targeted delivery and photothermal treatment.
协同治疗由于其优于大多数单一抗肿瘤方案的治疗效果，在癌症的近期治疗中引起了越来越多的关注。在此，我们设计了一种基于可生物降解脂质体的两药共载纳米系统，负载顺铂、吲哚菁绿（ICG）和与胆固醇衍生物（CJM-Chol）偶联的 CJM126，用于协同治疗。所得纳米粒粒径均一，平均粒径为 103.8nm，形态良好。近红外辐射（NIR）响应释放研究表明，NIR 介导的光热转换诱导脂质体可控药物释放。此外，设计的脂质体（仅 50μg/mL）在暴露于 808nm 近红外激光（1.54W，5min）时显示出令人鼓舞的光热转换效率，并达到高温（65.6°C，Tm=42°C）。此外，研究结果表明，该递药系统可以被肿瘤细胞有效内吞，这归因于其良好的生物相容性和叶酸的靶向作用。与游离顺铂（28.41%）或无 NIR 照射（11.24%）相比，本研究中添加照射后，制备的纳米粒对 MDA-MB-231 细胞的抑制效果明显更好（24h 时细胞活力为 3.05%）。我们的研究强调了目前的纳米粒为靶向递药和光热治疗提供了一种有前途的策略。
