Jones Matthew D, Wu Xujun, Chaudhuri Julian, Davidson Matthew G, Ellis Marianne J
Department of Chemistry, University of Bath, Bath BA2 7AY, UK.
Department of Chemistry, University of Bath, Bath BA2 7AY, UK; Department of Chemical Engineering, University of Bath, Bath BA2 7AY, UK.
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:69-74. doi: 10.1016/j.msec.2017.03.242. Epub 2017 Mar 29.
Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130°C. The zirconium-catalyzed PLA (PLA-Zr) required 30min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications.
在此，一种锆胺三（酚盐）被用作生产生物医学应用聚乳酸的引发剂，以替代锡引发剂（通常为辛酸亚锡）。开环聚合（ROP）在130°C的熔体中进行。锆催化的聚乳酸（PLA-Zr）反应需要30分钟，多分散指数（PDI）为1.17，而锡催化的聚乳酸（PLA-Sn）反应需要1小时，PDI为1.77。直到第14天，PLA-Zr和PLA-Sn对骨肉瘤细胞（MG63）培养的支持程度相同（细胞数量、形态、细胞外基质产生和成骨功能），之后PLA-Zr显示出细胞数量增加、整体细胞外基质产生和成骨功能增强。总之，锆胺三（酚盐）引发剂反应时间缩短、微观结构可控且具有生物良性，表明它是生物医学应用中聚乳酸ROP更有效的引发剂。
