Wang Xiyin, Ivan Mircea, Hawkins Shannon M
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States.
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Gynecol Oncol. 2017 Nov;147(2):481-487. doi: 10.1016/j.ygyno.2017.08.027. Epub 2017 Aug 31.
MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microRNA-regulatory machinery and mediate microRNA production and function. This review discusses aberrant expression of microRNA molecules and microRNA-regulating machinery associated with clinical features of epithelial ovarian cancer. Understanding the regulation of microRNA molecule production and function may facilitate the development of novel diagnostic and therapeutic strategies to improve the prognosis of women with epithelial ovarian cancer. Additionally, understanding microRNA molecules and microRNA-regulatory machinery associations with clinical features may influence prevention and early detection efforts.
微小RNA分子是小的单链RNA分子，其功能是调控基因网络。它们在正常女性生殖道生物学以及上皮性卵巢癌的发病机制和进展中发挥重要作用。DROSHA、DICER和AGO蛋白是微小RNA调控机制的组成部分，介导微小RNA的产生和功能。本综述讨论了与上皮性卵巢癌临床特征相关的微小RNA分子和微小RNA调控机制的异常表达。了解微小RNA分子产生和功能的调控可能有助于开发新的诊断和治疗策略，以改善上皮性卵巢癌女性患者的预后。此外，了解微小RNA分子和微小RNA调控机制与临床特征的关联可能会影响预防和早期检测工作。
