Drug Delivery, Disposition and Dynamics, and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Drug Delivery, Disposition and Dynamics, and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
J Colloid Interface Sci. 2017 Dec 15;508:517-524. doi: 10.1016/j.jcis.2017.08.079. Epub 2017 Aug 24.
Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM)+phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM+phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.
在此，我们报告了一种一氧化氮感应脂质基液晶（LLC）系统的开发，该系统专门设计用于通过刺激相变化在暴露于 NO 时释放封装的药物。设计并合成了一系列与植烷三醇和 GMO 立方相兼容的一氧化氮（NO）感应脂质，并用于实现一氧化氮感应 LLC 系统。NO 感应脂质与一氧化氮反应，导致这些脂质的水解和 LLC 系统的相转变。具体来说，N-3-氨基吡啶基肉豆蔻胺（NAPyM）+植烷三醇混合物在过量水相环境中形成层状相。NAPyM+植烷三醇 LLC 对一氧化氮气体作为化学刺激物做出响应，引发从层状相到反立方相和六方相的相转变。 LLC 的一氧化氮触发相转变加速了封装模型药物从 LLC 本体相的释放，与起始层状结构相比，扩散系数增加了 15 倍。一氧化氮感应 LLC 系统在开发治疗涉及一氧化氮的疾病的智能药物方面具有潜在应用。
