School of Sport, Exercise and Health Sciences, National Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, UK.
NIHR Leicester Biomedical Research Centre - Lifestyle, Leicester, UK.
Thorax. 2018 Jun;73(6):587-589. doi: 10.1136/thoraxjnl-2016-209870. Epub 2017 Sep 2.
Absence of established reference values limits application of quadriceps maximal voluntary contraction (QMVC) measurement. The impact of muscle mass inclusion in predictions is unclear. Prediction equations encompassing gender, age and size with (FFM+) and without (FFM-), derived in healthy adults (n=175), are presented and compared in two COPD cohorts recruited from primary care (COPD-PC, n=112) and a complex care COPD clinic (COPD-CC, n=189). Explained variance was comparable between the prediction models (R2: FFM+: 0.59, FFM-: 0.60) as were per cent predictions in COPD-PC (88.8%, 88.3%). However, fat-free mass inclusion reduced the prevalence of weakness in COPD, particularly in COPD-CC where 11.9% fewer were deemed weak.
由于缺乏既定的参考值，限制了股四头肌最大随意收缩（QMVC）测量的应用。肌肉质量纳入预测的影响尚不清楚。本研究在初级保健（COPD-PC，n=112）和复杂护理 COPD 诊所（COPD-CC，n=189）招募的两个 COPD 队列中，提出并比较了包含性别、年龄和大小（FFM+）和不包含（FFM-）的预测方程，并在健康成年人（n=175）中得出。预测模型之间的解释方差具有可比性（R2：FFM+：0.59，FFM-：0.60），COPD-PC 中的预测百分比也具有可比性（88.8%，88.3%）。然而，去除脂肪质量后，COPD 中的无力比例降低，在 COPD-CC 中尤其如此，其中无力的比例降低了 11.9%。
