精准医学与PET-CT在儿童恶性肿瘤中的应用
Precision Medicine and PET-Computed Tomography in Pediatric Malignancies.
作者信息
Sanli Yasemin, Yilmaz Ebru, Subramaniam Rathan M
机构信息
Department of Nuclear Medicine, Medical Faculty of Istanbul, Istanbul University, Sehremini, Istanbul 34370, Turkey; Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA.
Department of Nuclear Medicine, Medical Faculty of Istanbul, Istanbul University, Sehremini, Istanbul 34370, Turkey.
出版信息
PET Clin. 2017 Oct;12(4):423-435. doi: 10.1016/j.cpet.2017.05.009. Epub 2017 Jul 28.
Fluorine-18 fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT-based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.
氟-18氟脱氧葡萄糖（F-FDG）正电子发射断层显像-计算机断层扫描（PET-CT）在多种儿童恶性肿瘤的诊断、分期、治疗选择和治疗评估以及推动儿科患者的精准医疗方面发挥着重要作用。在霍奇金淋巴瘤患者中，中期氟脱氧葡萄糖F-FDG PET/CT对预测生存率具有高度敏感性和特异性，目前正在进行多项基于FDG PET/CT的适应性治疗试验。在检测神经母细胞瘤患者和肉瘤患者的转移灶方面，它优于碘-131间碘苄胍（I-MIBG）闪烁显像和骨闪烁显像。它可能预测肾母细胞瘤的组织学分化和新辅助治疗评估。
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