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可变多聚腺苷酸化在基因表达的调控和失调中的作用。

Alternative polyadenylation in the regulation and dysregulation of gene expression.

机构信息

Development and stem cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, 3800, Australia.

Development and stem cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, 3800, Australia.

出版信息

Semin Cell Dev Biol. 2018 Mar;75:61-69. doi: 10.1016/j.semcdb.2017.08.056. Epub 2017 Sep 1.

DOI:10.1016/j.semcdb.2017.08.056
PMID:28867199
Abstract

Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3'UTR.

摘要

转录控制决定了细胞的转录组组成，但 RNA 加工才是对其表达进行精细调控的关键。mRNA 的非翻译区（UTR）是调控的热点。这些区域的特征会影响 mRNA 的稳定性、定位和翻译。在这里，我们描述了可变剪接和多聚腺苷酸化如何通过改变其 3'UTR 的长度来改变 mRNA 的命运。

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