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本文引用的文献

1
Skin parasite landscape determines host infectiousness in visceral leishmaniasis.皮肤寄生虫状况决定内脏利什曼病的宿主传染性。
Nat Commun. 2017 Jul 5;8(1):57. doi: 10.1038/s41467-017-00103-8.
2
Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India.了解杜氏利什曼原虫的传播动态，为印度比哈尔邦消除内脏利什曼病的干预措施提供有力证据。
Parasit Vectors. 2016 Jan 27;9:25. doi: 10.1186/s13071-016-1309-8.
3
New Insights Into the Transmissibility of Leishmania infantum From Dogs to Sand Flies: Experimental Vector-Transmission Reveals Persistent Parasite Depots at Bite Sites.婴儿利什曼原虫从狗传播至白蛉的新见解：实验性媒介传播揭示了叮咬部位存在持久性寄生虫库。
J Infect Dis. 2016 Jun 1;213(11):1752-61. doi: 10.1093/infdis/jiw022. Epub 2016 Jan 14.
4
Heterogeneities in Leishmania infantum infection: using skin parasite burdens to identify highly infectious dogs.婴儿利什曼原虫感染的异质性：利用皮肤寄生虫负荷来识别高传染性犬只。
PLoS Negl Trop Dis. 2014 Jan 9;8(1):e2583. doi: 10.1371/journal.pntd.0002583. eCollection 2014.
5
Asymptomatic dogs are highly competent to transmit Leishmania (Leishmania) infantum chagasi to the natural vector.无症状犬对自然传播媒介具有高度传播查加斯利什曼原虫（Leishmania）的能力。
Vet Parasitol. 2013 Sep 23;196(3-4):296-300. doi: 10.1016/j.vetpar.2013.03.017. Epub 2013 Mar 21.
6
A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies.通过媒介沙蝇叮咬自然传播，在仓鼠中建立新型内脏利什曼病进展模型。
J Infect Dis. 2013 Apr 15;207(8):1328-38. doi: 10.1093/infdis/jis932. Epub 2013 Jan 3.
7
Leishmania development in sand flies: parasite-vector interactions overview.沙蝇体内利什曼原虫的发育：寄生虫-媒介相互作用概述。
Parasit Vectors. 2012 Dec 3;5:276. doi: 10.1186/1756-3305-5-276.
8
LeishVet guidelines for the practical management of canine leishmaniosis.利什曼病兽医临床管理指南。
Parasit Vectors. 2011 May 20;4:86. doi: 10.1186/1756-3305-4-86.
9
Leishmania donovani causing cutaneous leishmaniasis in Sri Lanka: a wolf in sheep's clothing?在斯里兰卡引起皮肤利什曼病的杜氏利什曼原虫：披着羊皮的狼？
Trends Parasitol. 2009 Oct;25(10):458-63. doi: 10.1016/j.pt.2009.07.002. Epub 2009 Sep 4.

片状寄生皮肤决定杜氏利什曼原虫向白蛉的传播。

Patchy Parasitized Skin Governs Leishmania donovani Transmission to Sand Flies.

作者信息

Kamhawi Shaden, Serafim Tiago D

机构信息

Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

出版信息

Trends Parasitol. 2017 Oct;33(10):748-750. doi: 10.1016/j.pt.2017.08.004. Epub 2017 Aug 31.

DOI:10.1016/j.pt.2017.08.004
PMID:28867329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5658035/
Abstract

Doehl et al. have combined empirical data with computer simulation to demonstrate that RAG-2 mice intravenously infected with Leishmania donovani form heterogeneous skin parasite patches that govern infectiousness to sand flies. This model provides a much-needed tool to explore the relevance of asymptomatic and symptomatic visceral leishmaniasis patients as infection reservoirs.

摘要

多尔等人将实证数据与计算机模拟相结合，以证明静脉注射杜氏利什曼原虫的RAG - 2小鼠会形成异质性皮肤寄生虫斑块，这些斑块决定了对沙蝇的传染性。该模型为探索无症状和有症状内脏利什曼病患者作为感染源的相关性提供了急需的工具。