Kamhawi Shaden, Serafim Tiago D
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Trends Parasitol. 2017 Oct;33(10):748-750. doi: 10.1016/j.pt.2017.08.004. Epub 2017 Aug 31.
Doehl et al. have combined empirical data with computer simulation to demonstrate that RAG-2 mice intravenously infected with Leishmania donovani form heterogeneous skin parasite patches that govern infectiousness to sand flies. This model provides a much-needed tool to explore the relevance of asymptomatic and symptomatic visceral leishmaniasis patients as infection reservoirs.
多尔等人将实证数据与计算机模拟相结合，以证明静脉注射杜氏利什曼原虫的RAG - 2小鼠会形成异质性皮肤寄生虫斑块，这些斑块决定了对沙蝇的传染性。该模型为探索无症状和有症状内脏利什曼病患者作为感染源的相关性提供了急需的工具。
