Freeman Lisa M, Rush John E, Stern Joshua A, Huggins Gordon S, Maron Martin S
Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, USA.
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, CCAH Room 258, One Shields Avenue, Davis, CA, USA.
Cardiol Res. 2017 Aug;8(4):139-142. doi: 10.14740/cr578w. Epub 2017 Aug 23.
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients.
肥厚型心肌病（HCM）是宠物猫中的常见疾病，影响10%至15%的宠物猫群体。猫HCM与人类HCM的相似性、疾病的快速进展以及猫HCM明确且易于确定的终点，使其成为一个在基因型和表型上与人类HCM相似的优秀天然模型。缅因猫和布偶猫因其肌球蛋白结合蛋白-C突变以及与整个猫科动物群体相比更高的疾病发病率，成为HCM特别有价值的模型。猫克服了啮齿动物HCM模型的许多局限性，能够加强从诱导性小动物模型到人类临床试验的信息转化。医生和兽医以协作和跨学科的方式共同工作，可以加快发现针对这种及其他影响人类和兽医患者的心血管疾病的更有效治疗方法。
