Ludwig H, Frühwald F, Tscholakoff D, Rasoul S, Neuhold A, Fritz E
Lancet. 1987 Aug 15;2(8555):364-6. doi: 10.1016/s0140-6736(87)92383-x.
The lower thoracic and lumbar spine of patients with multiple myeloma was examined by magnetic resonance imaging (MRI), plain radiography, and bone scintigraphy. Three independent investigators evaluated the power of these diagnostic methods to detect bone lesions in 192 vertebrae from 18 patients and in 60 vertebrae from 7 controls. 41 foci with abnormal signal intensity were detected by MRI; X-ray films showed osteolytic lesions in 4 vertebral bodies; and bone scanning was positive in 2 cases. The superiority of MRI in detecting myeloma-associated focal bone lesions was statistically significant, and in one case the lesions were confirmed at necropsy. Deviations in shape and height of vertebral bodies were slightly more easily visible on radiographs. Early detection of imminent medullary compressions in 2 patients led to successful radiotherapy before symptoms appeared.
采用磁共振成像（MRI）、X线平片和骨闪烁显像对多发性骨髓瘤患者的下胸椎和腰椎进行检查。三位独立的研究人员评估了这些诊断方法在18例患者的192个椎体以及7例对照的60个椎体中检测骨病变的能力。MRI检测到41个信号强度异常的病灶；X线片显示4个椎体有溶骨性病变；骨扫描有2例呈阳性。MRI在检测骨髓瘤相关局灶性骨病变方面的优越性具有统计学意义，1例病变在尸检时得到证实。椎体形状和高度的偏差在X线片上稍更容易观察到。2例患者即将发生髓内压迫的早期发现使得在症状出现前成功进行了放疗。
