Vaiopoulos G, Viniou N, Plata E, Konstantopoulos K, Andreopoulos A, Rombos Y, Meletis J, Loukopoulos D, Yataganas X
First Department of Internal Medicine, University of Athens Medical School, Laiko General Hospital, Greece.
Ann Hematol. 1996 May;72(5):317-20. doi: 10.1007/s002770050178.
Plasma cell tumors (plasmacytomas-PCT) of the bone, or extramedullary PCT, may be diagnosed in patients with or without the diagnostic criteria for systemic multiple myeloma (MM). The reason for the local development of these tumors is not clear. Recent reports emphasize the contribution of CT and MRI in the detection of bone lesions and their expansion into the soft tissues. We report the development of PCT in nine patients with MM under maintenance treatment with alpha-IFN, of whom six had no evidence of systemic relapse and three had indications of early relapse. The PCT were located in the pelvis (4), thoracic (3), cervical (1), and lumbar (2) spine and in 8/9 cases were not demonstrable on plain X-rays. These observations suggest that frequent screening with advanced imaging techniques may detect local disease expansion in asymptomatic patients. Early application of radiochemotherapy may improve prognosis.
骨浆细胞瘤（浆细胞瘤 - PCT）或髓外PCT，可在符合或不符合系统性多发性骨髓瘤（MM）诊断标准的患者中被诊断出来。这些肿瘤局部发生的原因尚不清楚。近期报告强调了CT和MRI在检测骨病变及其向软组织扩展方面的作用。我们报告了9例接受α - 干扰素维持治疗的MM患者发生PCT的情况，其中6例无系统性复发证据，3例有早期复发迹象。PCT位于骨盆（4例）、胸椎（3例）、颈椎（1例）和腰椎（2例），9例中有8例在X线平片上未显示。这些观察结果表明，采用先进成像技术进行频繁筛查可能检测出无症状患者的局部疾病扩展。早期应用放化疗可能改善预后。
