Greve Aja Neergaard, Mors Ole, Mortensen Erik Lykke, Meier Sandra Melanie, McGrath John J, Petersen Liselotte
Psychosis Research Unit, Aarhus University Hospital, Skovagervej 2, 8240 Risskov, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
Schizophr Res Cogn. 2017 Jul 26;9:18-22. doi: 10.1016/j.scog.2017.07.001. eCollection 2017 Sep.
Results from twin, family, and adoption studies all suggest that general intelligence is highly heritable. Several studies have shown lower premorbid intelligence in individuals before the onset of both mood disorders and psychosis, as well as in children and adolescents at genetic high risk for developing schizophrenia. Based on these findings, we aim to investigate if the association between educational achievement in parents and intelligence in their offspring is influenced by schizophrenia or mood disorder in parents. In a large population-based sample of young adult male conscripts (n = 156,531) the presence of a mental disorder in the parents were associated with significantly lower offspring scores on a test of general intelligence, the Børge Priens Prøve (BPP), and higher educational attainment in parents was significantly associated with higher BPP test scores in offspring. A significant interaction suggested that the positive association between maternal education and offspring intelligence was stronger in offspring of mothers with schizophrenia compared to the control group (p = ). The associations between parental education and offspring intelligence are also observed when restricting the sample to conscripts whose parents are diagnosed after 30 years of age. In conclusion, findings from this study show a more positive effect of education on offspring intelligence in mothers with schizophrenia compared to mothers from the control group. This effect could have both environmental and genetic explanations.
双胞胎、家族和收养研究的结果均表明，一般智力具有高度遗传性。多项研究显示，在情绪障碍和精神病发作之前，个体的病前智力较低，在患精神分裂症遗传风险较高的儿童和青少年中也是如此。基于这些发现，我们旨在调查父母的教育成就与子女智力之间的关联是否受父母患精神分裂症或情绪障碍的影响。在一个基于大量人群的年轻成年男性应征入伍者样本（n = 156,531）中，父母患有精神障碍与子女在一般智力测试——博尔格·普里恩斯测试（BPP）中的得分显著较低相关，而父母较高的教育程度与子女较高的BPP测试得分显著相关。一个显著的交互作用表明，与对照组相比，精神分裂症母亲的子女中，母亲教育程度与子女智力之间的正相关更强（p = ）。当将样本限制为父母在30岁之后被诊断出疾病的应征入伍者时，也观察到了父母教育程度与子女智力之间的关联。总之，本研究结果表明，与对照组母亲相比，精神分裂症母亲的教育对子女智力有更积极的影响。这种影响可能有环境和遗传两方面的解释。
