Ho Phoebe Wing-Lam, Pang Wing-Fai, Luk Cathy Choi-Wan, Ng Jack Kit-Chung, Chow Kai-Ming, Kwan Bonnie Ching-Ha, Li Philip Kam-Tao, Szeto Cheuk-Chun
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Kidney Dis (Basel). 2017 Jul;3(2):78-83. doi: 10.1159/000475883. Epub 2017 May 17.
Mitochondrial dysfunction contributes to the pathogenesis of acute kidney injury (AKI). The urinary mitochondrial DNA (mtDNA) level was previously shown to predict renal function recovery in AKI following cardiac surgery. Herein, we determine whether urinary mtDNA is a marker of severity and predictor of recovery in AKI due to other etiologies.
We recruited 107 AKI patients. The urinary mtDNA level was measured, the severity of AKI was quantified, and patients were followed for 90 days.
The urinary mtDNA level had modest but statistically significant correlations with the peak serum creatinine level (Spearman's = -0.248, = 0.010) and the duration of hospital stay ( = -0.217, = 0.025). Patients who required temporary dialysis also tended to have higher urinary mtDNA levels than those without dialysis (22.6 ± 4.5 vs. 24.9 ± 5.7 cycles, = 0.06). There was no definite relation between the urinary mtDNA level and renal function recovery.
The urinary mtDNA level is a marker of AKI severity, as reflected by its significant correlation with the peak serum creatinine level, duration of hospital stay, and probably the need for temporary dialysis. Our result suggests that urinary mtDNA has the potential to serve as a biomarker of AKI.
线粒体功能障碍在急性肾损伤（AKI）的发病机制中起作用。先前研究表明，尿线粒体DNA（mtDNA）水平可预测心脏手术后AKI患者的肾功能恢复情况。在此，我们确定尿mtDNA是否为其他病因所致AKI严重程度的标志物及恢复情况的预测指标。
我们招募了107例AKI患者。检测尿mtDNA水平，量化AKI严重程度，并对患者随访90天。
尿mtDNA水平与血清肌酐峰值水平呈中度但具有统计学意义的相关性（Spearman相关系数 = -0.248，P = 0.010），与住院时间呈相关性（ = -0.217，P = 0.025）。需要临时透析的患者尿mtDNA水平也往往高于未透析患者（22.6±4.5对24.9±5.7个循环，P = 0.06）。尿mtDNA水平与肾功能恢复之间无明确关系。
尿mtDNA水平是AKI严重程度的标志物，这体现在其与血清肌酐峰值水平、住院时间以及可能与临时透析需求之间的显著相关性上。我们的结果表明，尿mtDNA有潜力作为AKI的生物标志物。
