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Mol Cell Oncol. 2017 Apr 28;4(4):e1319896. doi: 10.1080/23723556.2017.1319896. eCollection 2017.
2
miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling.微小RNA-600作为一种双峰开关，通过WNT信号通路调节乳腺癌干细胞命运。
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本文引用的文献

1
miR-600 inhibits cell proliferation, migration and invasion by targeting p53 in mutant p53-expressing human colorectal cancer cell lines.在表达突变型p53的人结肠癌细胞系中，miR-600通过靶向p53抑制细胞增殖、迁移和侵袭。
Oncol Lett. 2017 Mar;13(3):1789-1796. doi: 10.3892/ol.2017.5654. Epub 2017 Jan 26.
2
miR-600 Acts as a Bimodal Switch that Regulates Breast Cancer Stem Cell Fate through WNT Signaling.微小RNA-600作为一种双峰开关，通过WNT信号通路调节乳腺癌干细胞命运。
Cell Rep. 2017 Feb 28;18(9):2256-2268. doi: 10.1016/j.celrep.2017.02.016.
3
Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells.简要综述：靶向上皮性癌干细胞样细胞的新型药物
Stem Cells. 2017 Apr;35(4):839-850. doi: 10.1002/stem.2579. Epub 2017 Mar 1.
4
Design of Multimodal Small Molecules Targeting miRNAs Biogenesis: Synthesis and In Vitro Evaluation.靶向微小RNA生物合成的多模态小分子设计：合成与体外评估
Methods Mol Biol. 2017;1517:137-154. doi: 10.1007/978-1-4939-6563-2_10.
5
Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity.干细胞与非干细胞癌细胞群体的双向相互转化：对肿瘤异质性理论模型的重新评估。
Mol Cell Oncol. 2015 Dec 2;3(2):e1098791. doi: 10.1080/23723556.2015.1098791. eCollection 2016 Mar.
6
Breast cancer stem cells programs: enter the (non)-code.乳腺癌干细胞程序：进入（非）编码状态。
Brief Funct Genomics. 2016 May;15(3):186-99. doi: 10.1093/bfgp/elw003. Epub 2016 Mar 8.
7
A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.微小 RNA miR-34a 调控的双模态开关靶向结肠癌干细胞中的 Notch。
Cell Stem Cell. 2013 May 2;12(5):602-15. doi: 10.1016/j.stem.2013.03.002.
8
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.干细胞的表观遗传动力学与细胞谱系定向分化：探寻沃丁顿的运河。
Nat Rev Mol Cell Biol. 2009 Aug;10(8):526-37. doi: 10.1038/nrm2727. Epub 2009 Jul 15.
9
Biological barriers to therapy with antisense and siRNA oligonucleotides.反义寡核苷酸和小干扰RNA寡核苷酸治疗的生物学障碍。
Mol Pharm. 2009 May-Jun;6(3):686-95. doi: 10.1021/mp900093r.

拨动癌症干细胞的开关以关闭癌症。

Flick the cancer stem cells' switch to turn cancer off.

作者信息

Ginestier Christophe, Birnbaum Daniel, Charafe-Jauffret Emmanuelle

机构信息

Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Molecular Oncology "Equipe labellisée Ligue Contre le Cancer," Marseille, France.

出版信息

Mol Cell Oncol. 2017 Apr 28;4(4):e1319896. doi: 10.1080/23723556.2017.1319896. eCollection 2017.

DOI:10.1080/23723556.2017.1319896
PMID:28868341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540206/
Abstract

Tumors are organized in a cellular hierarchy with a population of cancer stem cell (CSC) driving cancer progression and resistance to treatment. Recently, we identified miR-600 as a bimodal switcher that balances breast CSC-fate from a self-renewing to a differentiation state, with a direct impact on tumor progression.

摘要

肿瘤是按照细胞层次结构组织起来的，其中一群癌症干细胞（CSC）推动着癌症的进展和对治疗的抗性。最近，我们将miR-600鉴定为一种双峰切换因子，它能平衡乳腺CSC的命运，使其从自我更新状态转变为分化状态，这对肿瘤进展有直接影响。