Taenaka Yoshiyuki, Wakisaka Yoshinari, Masuzawa Toru, Tatsumi Eisuke, Toda Koichi, Miyazaki Koji, Eya Kazuhiro, Baba Yuzo, Nakatani Takeshi, Ohno Takashi, Nishimura Takashi, Takano Hisateru
National Cardiovascular Center, Osaka, Japan.
Artif Organs. 1996 May;20(5):491-496. doi: 10.1111/j.1525-1594.1996.tb04470.x.
A centrifugal pump with a unique structure has been developed for chronic support. The pump is driven by a magnetic coupling and has no rotating shaft, no seal around the rotating part, and a balancing hole at the center of the impeller and the thrust bearing. The pump was improved in stepwise fashion to realize good antithrombogenicity and low hemolysis. The first pump, the National Cardiovascular Center (NCVC)-O, had an impeller with 4 rectangular and curved vanes; 6 triangularly shaped curved vanes were employed in the second model, the NCVC-1, to reduce trauma to the blood. In the third design, the NCVC-2, the central hole was enlarged, and the thrust bearing shoulder was rounded so that blood washing was enhanced around the impeller; stream lines also were smoothed for improved antithrombogenicity. The hemolytic property of the device was evaluated in vitro with heparinized fresh goat blood; hemolysis indexes of the NCVC-0, -1, and -2 were 0.05, 0.01, and 0.006 g per 100 L, respectively. Antithrombogenicity of the pumps was examined in animal experiments as a left heart bypass device in goats weighing 52-75 kg. Six NCVC-0 pumps were driven for 14 to 33 (22.0 ± 7.6) days in goats receiving the antiplatelet drug cilostazol orally. Four NCVC-I pumps ran for 1 to 80 (28.5 ± 30.6) days with the same drug regimen in 2 cases and with no anticoagulation therapy in 2 cases. After 3 preliminary 1-week tests of NCVC-2 pumps in animals, the pump was installed in 3 goats; 2 pumps were still running on the 182nd and 58th pumping day. Intracorporeal implantation also was attempted successfully. The results indicate that this pump has promising features for chronic support although longer term and additional evaluations are necessary.
一种具有独特结构的离心泵已被开发用于长期支持。该泵由磁耦合驱动，没有旋转轴，旋转部件周围没有密封，叶轮中心和止推轴承处有一个平衡孔。该泵逐步改进以实现良好的抗血栓形成性和低溶血率。第一台泵，即国立心血管中心（NCVC）-O，有一个带有4个矩形弯曲叶片的叶轮；第二台型号NCVC-1采用了6个三角形弯曲叶片，以减少对血液的损伤。在第三种设计NCVC-2中，中心孔被扩大，止推轴承肩部被倒圆，以便增强叶轮周围的血液冲洗；流线也被平滑以改善抗血栓形成性。该装置的溶血特性在体外使用肝素化新鲜山羊血进行评估；NCVC-0、-1和-2的溶血指数分别为每100升0.05、0.01和0.006克。在动物实验中，作为体重52 - 75千克山羊的左心旁路装置，对这些泵的抗血栓形成性进行了检查。6台NCVC-0泵在口服抗血小板药物西洛他唑的山羊中运行了14至33（22.0±7.6）天。4台NCVC-I泵在2例中采用相同药物方案运行了1至80（28.5±30.6）天，在2例中未进行抗凝治疗。在对NCVC-2泵进行3次为期1周的动物初步测试后，该泵被安装在3只山羊体内；在第182天和第58天，2台泵仍在运行。体内植入也成功进行。结果表明，尽管需要进行更长期和更多的评估，但这种泵对于长期支持具有有前景的特性。
