Wakisaka Y, Taenaka Y, Chikanari K, Nakatani T, Tatsumi E, Masuzawa T, Nishimura T, Takewa Y, Ohno T, Takano H
Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
Artif Organs. 1997 Jul;21(7):639-44. doi: 10.1111/j.1525-1594.1997.tb03714.x.
Antithrombogenicity of a centrifugal pump (CP) developed in our institute is provided by a central balancing hole (BH) in the impeller. A current CP, the National Cardiovascular Center (NCVC)-2, was ameliorated to improve antithrombogenicity, whereby the BH diameter was widened to improve self washout flow velocity, and an edge of the thrust bearing was rounded off to minimize flow separation. Effects of these modifications were assessed in a long-term in vivo experiment. The antithrombogenicity, hemolytic property, and mechanical durability of the NCVC-2 were investigated in 3 goats. The NCVC-2 was installed paracorporeally between the left atrium and the aorta and driven as long as possible at rotating speeds of about 2,800 rpm. The NCVC-2 ran for 50, 200, and 367+ days. The mean bypass flow rates were 6.8, 5.0, and 5.3 L/min, respectively. Creatinine, blood urea nitrogen (BUN), glutamic-oxaloacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) did not increase until one week before termination. Plasma free hemoglobin was kept to a level less than 15 mg/dl, except for the last week of the second case. These results indicate that the NCVC-2 has excellent antithrombogenicity, an acceptable hemolytic property and the necessary durability for prolonged use.
我们研究所研发的离心泵（CP）的抗血栓形成特性由叶轮中的中央平衡孔（BH）提供。当前的CP，即国立心血管中心（NCVC）-2，为改善抗血栓形成特性进行了改良，将BH直径扩大以提高自冲洗流速，并将止推轴承的边缘倒圆以尽量减少流动分离。在长期体内实验中评估了这些改良措施的效果。在3只山羊身上研究了NCVC-2的抗血栓形成特性、溶血特性和机械耐久性。NCVC-2体外安装在左心房和主动脉之间，并以约2800转/分钟的转速尽可能长时间驱动。NCVC-2分别运行了50天、200天和367 +天。平均旁路流速分别为6.8升/分钟、5.0升/分钟和5.3升/分钟。肌酐、血尿素氮（BUN）、谷草转氨酶（GOT）和谷丙转氨酶（GPT）直到终止前一周才升高。除了第二例的最后一周外，血浆游离血红蛋白保持在低于15毫克/分升的水平。这些结果表明，NCVC-2具有优异的抗血栓形成特性、可接受的溶血特性以及长期使用所需的耐久性。
