Zhao Zhi, Yu Jia-Lin, Zhang Hai-Bo, Li Ju-Hua, Li Zhan-Kui
1 Children's Hospital of Chongqing Medical University, Chongqing, China.
2 Shanxi Province People's Hospital, Xi'an, Shaanxi Province, China.
Clin Pediatr (Phila). 2018 Apr;57(4):389-397. doi: 10.1177/0009922817728699. Epub 2017 Sep 4.
This study aimed to provide more data support for early diagnosis and treatment of neonatal purulent meningitis through retrospective analysis of its clinical diagnosis and treatment, pathogen distribution, and drug resistance in 5 third-class A hospitals in Southwest and Northwest China from January 2011 to December 2015. It was found that both the positive rates of blood and cerebrospinal fluid culture were low, and Escherichia coli should be the main pathogenic bacteria. Drug-resistant strains with varying degrees to the third generation of cephalosporin antibiotics have appeared currently.
本研究旨在通过回顾性分析2011年1月至2015年12月中国西南和西北地区5家三级甲等医院新生儿化脓性脑膜炎的临床诊断与治疗、病原菌分布及耐药情况，为其早期诊断和治疗提供更多数据支持。研究发现，血培养和脑脊液培养的阳性率均较低，大肠杆菌应为主要病原菌。目前已出现对第三代头孢菌素类抗生素有不同程度耐药的菌株。
