Cure Brain Cancer Foundation Biomarkers & Translational Research Group, Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Medical Sciences Division, University of Oxford, Oxford, UK.
Nanomedicine (Lond). 2017 Oct;12(19):2389-2401. doi: 10.2217/nnm-2017-0193. Epub 2017 Sep 4.
The prognosis of brain cancer glioblastoma (GBM) is poor, and despite intense research, there have been no significant improvements within the last decade. This stasis implicates the need for more novel therapeutic investigation. One such option is the use of nanoparticles (NPs), which can be beneficial due to their ability to penetrate the brain, overcome the blood-brain barrier and take advantage of the enhanced permeation and retention effect of GBM to improve specificity. Rare earth elements possess a number of interesting natural properties due to their unique electronic configuration, which may prove therapeutically advantageous in an NP formulation. The underexplored exciting potential for rare earth elements to augment the therapeutic potential of NPs in GBM treatment is discussed in this review.
脑癌胶质母细胞瘤（GBM）的预后较差，尽管进行了大量研究，但在过去十年中并没有取得重大进展。这种停滞不前意味着需要进行更多新的治疗研究。其中一种选择是使用纳米粒子（NPs），由于其能够穿透大脑、克服血脑屏障并利用 GBM 的增强渗透和保留效应的优势来提高特异性，因此具有一定的益处。由于其独特的电子构型，稀土元素具有许多有趣的天然特性，这在 NP 制剂中可能具有治疗优势。本文综述了探讨稀土元素在增强 NPs 治疗 GBM 中的治疗潜力方面的令人兴奋的潜力。
