Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
Front Endocrinol (Lausanne). 2021 Dec 20;12:774142. doi: 10.3389/fendo.2021.774142. eCollection 2021.
The extensive use of rare earth elements (REEs) in many technologies was found to have effects on human health, but the association between early pregnancy exposure to REEs and gestational diabetes mellitus (GDM) is still unknown.
This nested case-control study involved 200 pregnant women with GDM and 200 healthy pregnant women from the Peking University Birth Cohort in Tongzhou. We examined the serum concentrations of 14 REEs during early pregnancy and analyzed their associations with the risk of GDM.
When the elements were considered individually in the logistic regression model, no significant associations were found between REEs and GDM, after adjusting for confounding variables ( > 0.05). In weighted quantile sum (WQS) regression, each quartile decrease in the mixture index for REEs resulted in a 1.67-fold (95% CI: 1.12-2.49) increased risk of GDM. Neodymium (Nd), Praseodymium (Pr), and Lanthanum (La) were the most important contributors in the mixture.
The study findings indicated that early pregnancy exposure to lower levels of REE mixture was associated with an increased risk of GDM, and Nd, Pr, and La exhibited the strongest effects in the mixture.
研究发现，许多技术中广泛使用的稀土元素（REEs）会对人类健康产生影响，但早期妊娠暴露于 REEs 与妊娠糖尿病（GDM）之间的关系尚不清楚。
本巢式病例对照研究纳入了 200 名患有 GDM 的孕妇和 200 名来自通州区北京大学生育队列的健康孕妇。我们检测了孕早期血清中 14 种 REEs 的浓度，并分析了它们与 GDM 风险之间的关系。
在调整了混杂因素后（>0.05），逻辑回归模型中单独考虑REEs 时，REEs 与 GDM 之间没有显著关联。在加权分位数总和（WQS）回归中，REEs 混合物指标每降低一个四分位数，GDM 的风险增加 1.67 倍（95%CI：1.12-2.49）。钕（Nd）、镨（Pr）和镧（La）是混合物中最重要的贡献者。
研究结果表明，早期妊娠暴露于较低水平的 REE 混合物与 GDM 风险增加有关，而 Nd、Pr 和 La 在混合物中表现出最强的作用。
