Feldman S
N Engl Reg Allergy Proc. 1986 Jul-Aug;7(4):362-6. doi: 10.2500/108854186779045638.
The advent of H2-receptor antagonists has dramatically advanced the understanding and treatment of peptic ulcer disease. Ranitidine and cimetidine have been shown to be safe and effective in healing duodenal and gastric ulcers and in prevention of duodenal ulcer relapse. Due to differences in chemical structure, ranitidine is more potent and has a longer duration of action and fewer side effects than cimetidine. The current trend in therapy is toward less frequent dosing patterns with more attention toward controlling nocturnal acid secretion. Possibilities for other therapeutic uses of H2-receptor antagonists are suggested.
H2受体拮抗剂的出现极大地推动了对消化性溃疡疾病的认识和治疗。雷尼替丁和西咪替丁已被证明在治愈十二指肠溃疡和胃溃疡以及预防十二指肠溃疡复发方面是安全有效的。由于化学结构的差异，雷尼替丁比西咪替丁更有效，作用持续时间更长，副作用更少。目前的治疗趋势是采用给药频率更低的模式，同时更加注重控制夜间胃酸分泌。文中还提出了H2受体拮抗剂其他治疗用途的可能性。
