Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, 9th Dong Dan San Tiao, Dongcheng District, Beijing 100730, China.
Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China; Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, 9th Dong Dan San Tiao, Dongcheng District, Beijing 100730, China.
J Clin Neurosci. 2017 Nov;45:1-8. doi: 10.1016/j.jocn.2017.06.074. Epub 2017 Aug 30.
Alzheimer's disease (AD) is the most common type of dementia and has caused a major global health concern. Understanding the etiology of AD can be beneficial for the diagnosis and intervention of this disease. Genetics plays a vital role in the pathogenesis of AD. Research methods in genetics such as the linkage analysis, study of candidate genes, genome-wide association study (GWAS), and next-generation sequencing (NGS) technology help us map the genetic information in AD, which can not only provide a new insight into the pathogenesis of AD but also be beneficial for early targeted intervention of AD. This review summarizes the pathogenesis as well as the diagnostic and therapeutic value of genetics in AD.
阿尔茨海默病（AD）是最常见的痴呆症类型，已成为全球主要的健康关注点。了解 AD 的病因有助于对此病进行诊断和干预。遗传学在 AD 的发病机制中起着至关重要的作用。遗传学中的研究方法，如连锁分析、候选基因研究、全基因组关联研究（GWAS）和下一代测序（NGS）技术，有助于我们绘制 AD 的遗传信息图谱，不仅可以为 AD 的发病机制提供新的见解，还有助于对 AD 进行早期靶向干预。本综述总结了遗传学在 AD 中的发病机制以及在诊断和治疗方面的价值。
