Hajilou Rana, Farhud Dariush D, Zarif-Yeganeh Marjan
Tehran-East Branch, Islamic Azad University, Tehran, Iran.
Dr. Farhud Genetic Clinic, Tehran, Iran.
Iran J Public Health. 2024 Mar;53(3):663-670. doi: 10.18502/ijph.v53i3.15148.
We aimed to investigate two polymorphisms, and of in Alzheimer's disease (AD).
In the present case-control research, we collected blood samples from 117 AD patients and 130 controls from Alzheimer's Hospital, residents of Tehran, Iran during the winter 2020 to autumn 2022. Following extraction of DNA, Genotyping of polymorphisms and were examined by sequencing and ARMS/PCR approaches. We compared distributions of genotypes in both patient and healthy groups using the Chi-Square test.
Regarding rs157580, a statistically significant difference was observed in the GA genotype frequency between patient and healthy groups, in both univariate and multivariate modes with these results that have come respectively, and it can be regarded as a protection factor <0.05).. No significant difference was observed in the frequency of A and G alleles between patient and healthy groups. Besides, concerning rs8106922, the AG genotype frequency in research groups in both univariate and multivariate cases, with these results that have come respectively was significantly different (=0.003) & (=0.009). Regarding GG genotype, a statistically significant difference was observed between the patient and healthy groups in both univariate and multivariate cases, respectively (=0.419) & (=0.425). Significant differences were observed in the G allele frequency for rs8106922 in the healthy and patient groups (=0.007), it can be regarded as a potential protective factor.
It is possible to consider the gene as one of the potential genes concerning Alzheimer's disease.
我们旨在研究阿尔茨海默病（AD）中[基因名称]的两种多态性，即[具体多态性1]和[具体多态性2]。
在本病例对照研究中，我们于2020年冬季至2022年秋季期间，从伊朗德黑兰阿尔茨海默病医院收集了117例AD患者和130名对照者的血样。提取DNA后，通过测序和ARMS/PCR方法检测[基因名称]多态性[具体多态性1]和[具体多态性2]的基因分型。我们使用卡方检验比较患者组和健康组中基因型的分布。
关于rs157580，在单变量和多变量模式下，患者组和健康组之间的GA基因型频率均观察到统计学上的显著差异，结果分别为[具体数值1]和[具体数值2]，可将其视为保护因素（<0.05）。患者组和健康组之间的A和G等位基因频率未观察到显著差异。此外，关于rs8106922，在单变量和多变量情况下，研究组中的AG基因型频率，结果分别为[具体数值3]和[具体数值4]，差异有统计学意义（=0.003）和（=0.009）。关于GG基因型，在单变量和多变量情况下，患者组和健康组之间分别观察到统计学上的显著差异（=0.419）和（=0.425）。在rs8106922的G等位基因频率方面，健康组和患者组之间观察到显著差异（=0.007），可将其视为潜在的保护因素。
有可能将[基因名称]基因视为与阿尔茨海默病相关的潜在基因之一。
