Toberer Ferdinand, Rütten Arno, Requena Luis, Kazakov Dmitry V, Enk Alexander, Hartschuh Wolfgang, Haenssle Holger A
Department of Dermatology, Venerology and Allergology, University Medical Center, Ruprecht-Karls-University, Heidelberg, Germany.
Dermatopathology Friedrichshafen, Friedrichshafen, Germany.
J Cutan Pathol. 2017 Nov;44(11):986-990. doi: 10.1111/cup.13031. Epub 2017 Sep 4.
We present the case of a 35-year-old man who developed a follicular differentiated cutaneous carcinoma with an eosinophil-rich infiltrate and an aggressive clinical behavior. After an in-depth histopathological investigation the diagnosis of trichoblastic carcinoma was made. Over the course of the disease the patient developed a cutaneous in-transit metastasis as well as an axillary lymph node metastasis 18 months after the excision of the primary tumor on his back. Based on a literature review we discuss the different concepts behind the term "trichoblastic carcinoma" and we summarize the clinical and histological details of previously reported cases. Furthermore, we focus on the phenomenon of tumor-associated eosinophilia.
我们报告了一例35岁男性病例，该患者患有一种伴有嗜酸性粒细胞丰富浸润和侵袭性临床行为的滤泡分化型皮肤癌。经过深入的组织病理学检查，诊断为毛发母细胞癌。在疾病过程中，患者在背部原发性肿瘤切除18个月后出现了皮肤转移灶以及腋窝淋巴结转移。基于文献综述，我们讨论了“毛发母细胞癌”这一术语背后的不同概念，并总结了先前报道病例的临床和组织学细节。此外，我们重点关注肿瘤相关嗜酸性粒细胞增多现象。
