The Ohio State University College of Medicine, Columbus, OH, USA.
Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Arch Dermatol Res. 2022 Jul;314(5):399-403. doi: 10.1007/s00403-021-02241-y. Epub 2021 May 15.
Trichoblastic carcinoma is a rare neoplasm thought to arise from malignant degeneration of benign follicular tumors. Its clinical features, optimal treatment, and outcomes remain largely unknown. We performed a comprehensive review of the existing trichoblastic carcinoma literature. PubMed and Google Scholar were searched for keywords related to trichoblastic carcinoma, and additional articles were found in reference lists. Cases with a histopathologic diagnosis of trichoblastic carcinoma were summarized. A total of 93 cases have been described, all in case reports or case series. The average age was 65, with 66.7% of cases in males. A minority of patients had familial tumor syndromes or a history of radiation at the site, and only one was reported to be immunosuppressed. The most common site was the face (48.4%), and the majority developed de novo (87.1%). The clinical presentation was highly variable. Although most cases (82.8%) were successfully treated with surgery alone, a subset of patients had more aggressive disease including local progression or recurrence in five cases, nodal metastases in five cases, and distant metastases in three cases. Trichoblastic carcinoma is a rare malignancy with the potential for aggressive behavior. Further research is needed to better characterize this neoplasm.
毛母质瘤是一种罕见的肿瘤，被认为起源于良性滤泡肿瘤的恶性转化。其临床特征、最佳治疗方法和预后在很大程度上仍不清楚。我们对现有的毛母质瘤文献进行了全面回顾。在 PubMed 和 Google Scholar 上搜索了与毛母质瘤相关的关键词，并在参考文献中找到了其他文章。总结了具有毛母质瘤组织病理学诊断的病例。共描述了 93 例病例，均为病例报告或病例系列。平均年龄为 65 岁，男性占 66.7%。少数患者有家族性肿瘤综合征或该部位放疗史，只有 1 例报告为免疫抑制。最常见的部位是面部（48.4%），大多数为初发（87.1%）。临床表现高度多变。尽管大多数病例（82.8%）仅通过手术成功治疗，但部分患者疾病更为侵袭性，包括 5 例局部进展或复发、5 例淋巴结转移和 3 例远处转移。毛母质瘤是一种罕见的恶性肿瘤，具有潜在的侵袭性行为。需要进一步的研究来更好地描述这种肿瘤。
