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N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D-2-氨基-5-磷酰戊酸（D-APV）可抑制正常吗啡在大鼠海马切片中产生的兴奋性活动。

NMDA receptor antagonist D-APV depresses excitatory activity produced by normorphine in rat hippocampal slices.

作者信息

Swearengen E, Chavkin C

出版信息

Neurosci Lett. 1987 Jul 9;78(1):80-4. doi: 10.1016/0304-3940(87)90565-9.

DOI:10.1016/0304-3940(87)90565-9
PMID:2886961
Abstract

Both pentylenetetrazole and normorphine increased CA1 pyramidal cell sensitivity to afferent stimulation and caused the appearance of synchronous afterpotentials (secondary spikes). D-2-Amino-5-phosphonovalerate (D-APV) attenuated secondary spikes induced by both drugs, but had no effect on the change in excitability of the primary population spike. These results suggest that both opiates and GABA receptor antagonists are able to unmask NMDA receptors in the in vitro rat hippocampus slice preparation.

摘要

戊四氮和去甲吗啡均可增加CA1锥体细胞对传入刺激的敏感性，并导致同步后电位（继发性锋电位）的出现。D-2-氨基-5-磷酸戊酸（D-APV）可减弱这两种药物诱导的继发性锋电位，但对初级群体锋电位的兴奋性变化无影响。这些结果表明，阿片类药物和GABA受体拮抗剂均可在体外大鼠海马脑片制备中使NMDA受体暴露。

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NMDA receptor antagonist D-APV depresses excitatory activity produced by normorphine in rat hippocampal slices.N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D-2-氨基-5-磷酰戊酸（D-APV）可抑制正常吗啡在大鼠海马切片中产生的兴奋性活动。
Neurosci Lett. 1987 Jul 9;78(1):80-4. doi: 10.1016/0304-3940(87)90565-9.
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Comparison of opioid and GABA receptor control of excitability and membrane conductance in hippocampal CA1 pyramidal cells in rat.大鼠海马CA1锥体细胞中阿片类受体与GABA受体对兴奋性和膜电导的控制比较
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The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-5-磷酸基戊酸可阻断大鼠海马切片中刺激序列诱导的癫痫发生，但不能阻断癫痫样爆发。
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Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice.N-甲基-D-天冬氨酸受体在大鼠海马切片癫痫样爆发中的作用。
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A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.一种选择性N-甲基-D-天冬氨酸拮抗剂可抑制大鼠海马切片中的癫痫样活动。
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APV, an N-methyl-D-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats.APV是一种N-甲基-D-天冬氨酸受体拮抗剂，可阻断行为学实验大鼠的海马θ节律。
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The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.N-甲基-D-天冬氨酸拮抗剂氨基磷酸戊酸和MK-801可减轻大鼠海马切片中齿状颗粒细胞和CA1锥体细胞的缺氧损伤。
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