Leung L W, Desborough K A
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Brain Res. 1988 Oct 25;463(1):148-52. doi: 10.1016/0006-8993(88)90538-0.
2-Aminophosphonovaleric acid (APV), an N-methyl-D-aspartate (NMDA) receptor antagonist, was infused into the lateral ventricles of behaving rats. A 10 or 20 microgram dose of APV attenuated the hippocampal theta rhythm and the theta phase-shift at the apical dendrites of hippocampal CA1 region. A selective suppression of the atropine-sensitive theta rhythm was suggested.
2-氨基膦戊酸（APV），一种N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，被注入到行为大鼠的侧脑室。10或20微克剂量的APV减弱了海马θ节律以及海马CA1区顶端树突处的θ相移。提示对阿托品敏感的θ节律有选择性抑制作用。
