[纳米抗体在癌症治疗中的应用]

[Application of nanobody in cancer treatment].

作者信息

Wu Yue, Hao Xiujing, Li Min

机构信息

Key Laboratory for Conservation and Utilization of Special Biological Resources in the Western China, Ministry of Education, Ningxia University, Yinchuan 750021, Ningxia, China.

出版信息

Sheng Wu Gong Cheng Xue Bao. 2017 Jul 25;33(7):1085-1090. doi: 10.13345/j.cjb.160491.

DOI:10.13345/j.cjb.160491

PMID:28869728

Abstract

Camelidae can produce a unique antibody that lacks light chain called variable heavy chain domain, also known as nanobodies. This antibody contains only one variable region, with high affinity, high stability, strong tissue penetration, efficient expression. Besides, their toxicity and immunogenicity are both low to be used for both therapeutic and diagnostic applications, as well as research tools. In this review, we discuss how nanobody has been explored as therapeutics in oncology, and provide ideas for the further development of nanobody.

摘要

骆驼科动物能够产生一种独特的抗体，这种抗体缺乏轻链，称为可变重链结构域，也被称为纳米抗体。这种抗体仅包含一个可变区，具有高亲和力、高稳定性、强组织穿透性和高效表达。此外，它们的毒性和免疫原性都很低，可用于治疗和诊断应用以及研究工具。在这篇综述中，我们讨论了纳米抗体如何被开发用于肿瘤治疗，并为纳米抗体的进一步发展提供思路。