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5-羟色胺和尼古丁对传出性肾交感神经活动的反射性抑制是由不同的心外膜受体引发的。

Reflex inhibition of efferent renal sympathetic nerve activity by 5-hydroxytryptamine and nicotine is elicited by different epicardial receptors.

作者信息

Mohr B, Bom A H, Kaumann A J, Thämer V

出版信息

Pflugers Arch. 1987 Jun;409(1-2):145-51. doi: 10.1007/BF00584763.

DOI:10.1007/BF00584763
PMID:2886974
Abstract

Intrapericardial administration of 5-hydroxytryptamine (5-HT) induced reflex effects consisting in an inhibition of renal sympathetic nerve activity (RSNA), bradycardia and a fall in blood pressure. Nicotine caused the same reflex effects as 5-HT. The reflex effects of both 5-HT and nicotine were abolished by vagotomy. MDL 72222, an antagonist at 5-HT M-receptors, abolished or attenuated the decreases in RSNA, heart rate and blood pressure induced by 5-HT, leaving the reflex effects of nicotine unchanged. In the absence of MDL 72222 the reflex bradycardia partially concealed a positive chronotropic response to 5-HT. After blockade of the bradycardia response by MDL 72222, 5-HT elicited a significant tachycardia, which was not altered by propranolol and phentolamine, but was prevented by phenoxybenzamine. 5-HT probably reaches the sinoatrial node and activates 5-HT receptors that mediate directly the increase in heart rate. The nicotine receptor antagonist hexamethonium selectively abolished or attenuated the reflex effects of nicotine without interfering with those of 5-HT. We conclude that 5-HT and nicotine elicit similar reflex effects in epicardial vagal nerve endings by stimulation of M-receptors or nicotine receptors, respectively.

摘要

在心包内给予5-羟色胺（5-HT）可诱发反射效应，包括抑制肾交感神经活动（RSNA）、心动过缓和血压下降。尼古丁产生与5-HT相同的反射效应。5-HT和尼古丁的反射效应均被迷走神经切断术消除。5-HT M受体拮抗剂MDL 72222消除或减弱了5-HT引起的RSNA、心率和血压下降，而尼古丁的反射效应未改变。在没有MDL 72222的情况下，反射性心动过缓部分掩盖了对5-HT的正性变时反应。在用MDL 72222阻断心动过缓反应后，5-HT引起显著的心动过速，普萘洛尔和酚妥拉明对此无改变，但苯氧苄胺可阻止。5-HT可能到达窦房结并激活直接介导心率增加的5-HT受体。尼古丁受体拮抗剂六甲铵选择性地消除或减弱了尼古丁的反射效应，而不干扰5-HT的反射效应。我们得出结论，5-HT和尼古丁分别通过刺激M受体或尼古丁受体，在心外膜迷走神经末梢引发相似的反射效应。

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本文引用的文献

1
The vascular action of natural serotonin, 5- and 7-hydroxytryptamine and tryptamine.天然血清素、5-羟色胺、7-羟色胺及色胺的血管作用。
J Pharmacol Exp Ther. 1952 May;105(1):58-73.
2
Impulses in vagal afferent fibres from specific pulmonary deflation receptors: the response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine and nicotine, and their rôle in respiratory and cardiovascular reflexes.来自特定肺萎陷感受器的迷走神经传入纤维冲动：这些感受器对苯双胍、马铃薯淀粉、5-羟色胺和尼古丁的反应及其在呼吸和心血管反射中的作用。
Q J Exp Physiol Cogn Med Sci. 1955 Apr;40(2):89-111. doi: 10.1113/expphysiol.1955.sp001116.
3
Cardiovascular and respiratory actions of 5-hydroxytryptamine in the cat.
5-羟色胺对猫心血管及呼吸系统的作用
Br J Pharmacol Chemother. 1955 Mar;10(1):66-72. doi: 10.1111/j.1476-5381.1955.tb00062.x.
4
Principles of pharmacological influence on coronary chemoreflexes.药物对冠状动脉化学反射影响的原理。
Arch Int Pharmacodyn Ther. 1962 Dec 1;140:646-54.
5
The action of histamine and 5-hydroxytryptamine on isolated mammalian atria.组胺和5-羟色胺对离体哺乳动物心房的作用。
J Pharmacol Exp Ther. 1960 Dec;130:450-60.
6
Two kinds of tryptamine receptor.两种色胺受体。
Br J Pharmacol Chemother. 1957 Sep;12(3):323-8. doi: 10.1111/j.1476-5381.1957.tb00142.x.
7
Species differences in the respiratory and cardiovascular response to serotonin (5-hydroxytryptamine).血清素（5-羟色胺）对呼吸和心血管反应的物种差异。
J Pharmacol Exp Ther. 1954 May;111(1):84-98.
8
The action of 5-hydroxytryptamine on pulmonary and cardiovascular vagal afferent fibres and its reflex respiratory effects.5-羟色胺对肺和心血管迷走传入纤维的作用及其反射性呼吸效应。
Br J Pharmacol Chemother. 1953 Jun;8(2):238-41. doi: 10.1111/j.1476-5381.1953.tb00786.x.
9
Reflex and direct cardiopulmonary effects of 5-OH-tryptamine (serotonin); their possible role in pulmonary embolism and coronary thrombosis.5-羟色胺（血清素）的反射性及直接心肺效应；它们在肺栓塞和冠状动脉血栓形成中的可能作用。
Am J Physiol. 1953 Jun;173(3):379-86. doi: 10.1152/ajplegacy.1953.173.3.379.
10
Effects of anesthesia on the canine carotid chemoreceptor reflex.麻醉对犬颈动脉化学感受器反射的影响。
Circ Res. 1981 Mar;48(3):400-6. doi: 10.1161/01.res.48.3.400.