Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Insititute, China.
Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Insititute, China.
Biomed Pharmacother. 2017 Nov;95:564-570. doi: 10.1016/j.biopha.2017.08.116. Epub 2017 Sep 12.
SPOCK1 belongs to the SPARC family, which plays an important role in proliferation, invasion and migration of various tumour cells. However, the functions of SPOCK1 in osteosarcoma cell growth and proliferation have not been fully elucidated. In the present study, we found that SPOCK1 is significantly upregulated in osteosarcoma tissue. Moreover, overexpression of SPOCK1 was associated with tumour size, metastasis, Enneking stage and pathological degree. Furthermore, knockdown of SPOCK1 expression suppressed the growth of osteosarcoma cells in vitro and reduced tumourigenicity in nude mice in vivo. Additionally, our data suggest that inactivation of the mTOR-S6K signaling pathway participated in inhibition of SPOCK1-mediated suppression of osteosarcoma cell growth. These findings represent a novel pathogenetic mechanism of osteosarcoma development that provides a potential target for therapeutic strategies for osteosarcoma.
SPOCK1 属于 SPARC 家族，在各种肿瘤细胞的增殖、侵袭和迁移中发挥重要作用。然而，SPOCK1 在骨肉瘤细胞生长和增殖中的功能尚未完全阐明。本研究发现，SPOCK1 在骨肉瘤组织中显著上调。此外，SPOCK1 的过表达与肿瘤大小、转移、Enneking 分期和病理程度有关。进一步的研究表明，敲低 SPOCK1 的表达可抑制骨肉瘤细胞在体外的生长，并降低裸鼠体内的肿瘤生成能力。此外，我们的数据表明，mTOR-S6K 信号通路的失活参与了 SPOCK1 介导的对骨肉瘤细胞生长的抑制作用。这些发现代表了骨肉瘤发生的一种新的发病机制，为骨肉瘤的治疗策略提供了一个潜在的靶点。
