Injury Prevention Research Center, University of North Carolina at Chapel Hill, 137 East Franklin Street, Suite 500, Chapel Hill, NC 27599-7505, United States; Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 421C Rosenau Hall, CB #7445, Chapel Hill, NC 27599-7505, United States.
Injury Prevention Research Center, University of North Carolina at Chapel Hill, 137 East Franklin Street, Suite 500, Chapel Hill, NC 27599-7505, United States; Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 421C Rosenau Hall, CB #7445, Chapel Hill, NC 27599-7505, United States.
Addict Behav. 2018 Jan;76:265-269. doi: 10.1016/j.addbeh.2017.08.033. Epub 2017 Sep 1.
Previous research has examined the association of childhood abuse with opioid misuse and dependence in adulthood. However, little research has focused specifically on prescription opioids, and no studies have examined associations with prescription opioid use, a potential pathway to later opioid misuse and dependence. The aim of the present study was to examine the association of childhood emotional, physical, and sexual abuse with prescription opioid use in early adulthood.
We used data from Waves I (12-18years) and IV (24-32years) of the National Longitudinal Study of Adolescent to Adult Health. At Wave IV, respondents reported experiences of childhood abuse occurring prior to age 18years and prescription opioid use in the last four weeks. We conducted multivariable logistic regression to examine associations of childhood abuse with recent prescription opioid use.
In multivariable models adjusted for respondent sex, race/ethnicity, age, and socioeconomic status, childhood emotional abuse (OR=1.57, 95% CI 1.29, 1.90), physical abuse (OR=1.46, 95% CI 1.14, 1.87), and any childhood abuse (OR=1.51, 95% CI 1.24, 1.82) were significantly associated with recent prescription opioid use.
Given continued increases in prescription opioid use and opioid-related morbidity and mortality in the U.S., understanding upstream social and environmental factors associated with prescription opioid use is important to strengthening and expanding current prevention and intervention strategies. Future research is needed to examine factors potentially mediating the association between childhood abuse and prescription opioid use in order to provide additional insights for prevention and intervention efforts.
先前的研究已经检验了儿童期虐待与成年后阿片类药物滥用和依赖之间的关联。然而，很少有研究专门关注处方阿片类药物，也没有研究检验与处方阿片类药物使用之间的关联，而后者是以后滥用和依赖阿片类药物的潜在途径。本研究旨在检验儿童期情感、身体和性虐待与成年早期处方阿片类药物使用之间的关联。
我们使用了来自国家青少年至成人健康纵向研究的第 I 波（12-18 岁）和第 IV 波（24-32 岁）的数据。在第 IV 波，受访者报告了 18 岁之前发生的童年期虐待经历和过去四周内的处方阿片类药物使用情况。我们进行了多变量逻辑回归分析，以检验童年期虐待与最近使用处方阿片类药物之间的关联。
在调整了受访者性别、种族/族裔、年龄和社会经济地位的多变量模型中，童年期情感虐待（OR=1.57，95%置信区间 1.29，1.90）、身体虐待（OR=1.46，95%置信区间 1.14，1.87）和任何形式的儿童期虐待（OR=1.51，95%置信区间 1.24，1.82）与最近使用处方阿片类药物显著相关。
鉴于美国处方阿片类药物使用以及与阿片类药物相关的发病率和死亡率持续上升，了解与处方阿片类药物使用相关的上游社会和环境因素对于加强和扩大当前的预防和干预策略至关重要。未来的研究需要检验潜在中介儿童期虐待与处方阿片类药物使用之间关联的因素，以便为预防和干预工作提供更多的见解。
