Richards Christopher J, Graf Kenneth W, Mashru Rakesh P
Department of Orthopaedic Surgery, Cooper University Hospital, 3 Cooper Plaza, Camden, NJ 08103, USA.
Department of Orthopaedic Surgery, Cooper Medical School of Rowan University, 401 South Broadway, Camden, NJ 08103, USA.
Orthop Clin North Am. 2017 Oct;48(4):433-443. doi: 10.1016/j.ocl.2017.06.002. Epub 2017 Jul 29.
The estimated rate of fracture nonunion is between 5% and 10%, adding significant cost to the health care system. The cause of fracture nonunion is multifactorial, including the severity of the injury, patient factors resulting in aberrancies in the biology of fracture, and the side effects of pain control modalities. Minimizing surgeon-controlled factors causing nonunion is important to reduce the cost of health care and improve patient outcomes. Opioids, alcohol, and nonsteroidal anti-inflammatory drugs have been implicated as risk factors for fracture nonunion. Current literature was reviewed to examine the effects of opioids, alcohol, and nonsteroidal anti-inflammatory drugs on fracture union.
骨折不愈合的估计发生率在5%至10%之间，给医疗保健系统增加了巨大成本。骨折不愈合的原因是多方面的，包括损伤的严重程度、导致骨折生物学异常的患者因素以及疼痛控制方式的副作用。尽量减少导致不愈合的外科医生可控因素对于降低医疗保健成本和改善患者预后非常重要。阿片类药物、酒精和非甾体抗炎药已被认为是骨折不愈合的危险因素。对现有文献进行了综述，以研究阿片类药物、酒精和非甾体抗炎药对骨折愈合的影响。
