Van Oss S Branden, Cucinotta Christine E, Arndt Karen M
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Trends Biochem Sci. 2017 Oct;42(10):788-798. doi: 10.1016/j.tibs.2017.08.003. Epub 2017 Sep 1.
The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that build on foundational studies in budding yeast. These studies identify new roles for Paf1C in the control of gene expression and the regulation of chromatin structure. In exploring these advances, we find that various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent. As more becomes known about the role of Paf1C in human disease, interest in the molecular mechanisms underpinning Paf1C function will continue to increase.
保守的多功能聚合酶相关因子1复合物（Paf1C）调节RNA聚合酶（Pol）II转录周期的所有阶段。在本综述中，我们研究了一系列来自不同生物体的最新研究，这些研究建立在芽殖酵母基础研究之上。这些研究确定了Paf1C在基因表达控制和染色质结构调节中的新作用。在探索这些进展时，我们发现Paf1C的各种功能，如高等真核生物中启动子近端暂停的调节和发育，是复杂且依赖于上下文的。随着人们对Paf1C在人类疾病中的作用了解得越来越多，对支撑Paf1C功能的分子机制的兴趣将持续增加。
