Gjerdet N R, Kallus T, Hensten-Pettersen A
Acta Odontol Scand. 1987 Jun;45(3):163-9. doi: 10.3109/00016358709098855.
Tissue response to a Fe-Cr-Ni and a Co-Cr-Ni orthodontic wire, in the as-received state and with silver soldered joints, was investigated. Specimens with polytetrafluoroethylene (PTFE) as a reference material were implanted in the subcutaneous tissue of rabbits. Six rabbits were sensitized to nickel, four animals were sham-sensitized, and two were left untreated. The results showed that the as-received wires gave no tissue response relative to the PTFE control. In soldered specimens that were moderate to extreme reactions adjacent to the soldered joint and around the wire portion as well. The soldered Co-Cr-Ni wire elicited the most severe reactions, most pronounced in the nickel-sensitized animals. The agar overlay cell culture test of some retrieved implants showed pronounced cytotoxicity of the soldered specimens. Leachable toxic components of the silver solder seemed to be of major importance in the observed cell culture and tissue response to the soldered specimens.
研究了处于原始状态以及带有银焊接头的铁铬镍和钴铬镍正畸丝的组织反应。将以聚四氟乙烯（PTFE）作为参考材料的样本植入兔的皮下组织。六只兔对镍致敏，四只动物进行假致敏，两只未处理。结果表明，原始状态的正畸丝相对于PTFE对照未引起组织反应。在焊接样本中，焊接接头附近以及丝部分周围出现中度至极端反应。焊接的钴铬镍丝引起的反应最为严重，在镍致敏动物中最为明显。对一些回收植入物进行的琼脂覆盖细胞培养试验显示，焊接样本具有明显的细胞毒性。银焊料中可浸出的有毒成分似乎在观察到的细胞培养和组织对焊接样本的反应中起主要作用。
