唾液腺恶性肿瘤切除术后的结局和预后因素：基于单一机构12年经验的研究

Outcomes and Prognostic Factors of Resected Salivary Gland Malignancies: Examining a Single Institution's 12-year Experience.

作者信息

Gutschenritter Tyler, Machiorlatti Michael, Vesely Sara, Ahmad Bilal, Razaq Wajeeha, Razaq Mohammad

机构信息

College of Medicine, Department of Medicine - Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.

Department of Biostatistics and Epidemiology, Department of Medicine - Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.

出版信息

Anticancer Res. 2017 Sep;37(9):5019-5025. doi: 10.21873/anticanres.11916.

DOI:10.21873/anticanres.11916

PMID:28870928

Abstract

BACKGROUND

Despite adjuvant radiotherapy, survival outcomes remain poor in patients with salivary gland malignancies who have multiple poor prognostic factors. This study aimed to determine which patients may benefit from treatment intensification.

PATIENTS AND METHODS

Patients who underwent curative resection with or without adjuvant radiotherapy between 2002 and 2014 were identified and a retrospective chart review was performed. Overall survival (OS) and disease-free survival (DFS) were the main outcomes measured.

RESULTS

A total of 95 patients met the inclusion criteria. The median follow-up was 46.8 months. The median age was 60 years. Radiotherapy was given to 78 patients. Multivariate analysis revealed that male sex and perineural invasion significantly reduced overall and disease-free survival. Distant metastases comprised of 67% of recurrences and 33% were locoregional.

CONCLUSION

Adjuvant chemoradiotherapy should be considered for patients with tumors with perineural invasion, especially in males with high-risk histopathology or high-grade, late-stage disease. To our knowledge, this is the first study to assess the impact of pack-year smoking history on survival outcomes.

摘要