Pan Elizabeth, Tung Lily, Ragab Omar, Morocco Elise, Wecsler Julie, Sposto Richard, Raghavendra Akshara, Chung Eugene, Lang Julie E
Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A.
Los Angeles County and University of Southern California Medical Center Department of Surgery and Norris Comprehensive Cancer Center, Division of Breast, Soft Tissue and Endocrine Surgery, University of Southern California, Los Angeles, CA, U.S.A.
Anticancer Res. 2017 Sep;37(9):5057-5063. doi: 10.21873/anticanres.11922.
Evidence on the management of inflammatory breast cancer (IBC) is limited. This study investigated factors influencing IBC treatment outcomes such as event-free survival (EFS) and overall survival (OS).
Data were collected from 173 patients with stage III non-IBC and 17 patients with IBC diagnosed at the Keck Medical Center and Los Angeles County and University of Southern California (LAC+USC) Medical Center. Cox proportional hazard regression evaluated associations between variables significant for EFS and OS.
On multivariate analysis, negative estrogen receptor (ER)status [hazard ratio (HR)=1.88, 95% confidence interval (CI)=1.11-3.18, p<0.06) and lack of postoperative radiation treatment (HR=2.07, 95% CI=1.03-4.15, p<0.04) were significant for poorer EFS. High Scarff-Bloom-Richardson (SBR) score (HR=2.24, 95% CI=0.79-6.36, p<0.13) and lack of postoperative radiation treatment to the breast (HR=4.39, 95% CI=0.39-49.55, p<0.23) were associated with lower rates of OS.
The diagnosis of IBC has a significantly worse prognosis. Receipt of post-mastectomy radiation therapy was a significant predictor of better EFS and OS.
关于炎性乳腺癌（IBC）治疗的证据有限。本研究调查了影响IBC治疗结果的因素，如无事件生存期（EFS）和总生存期（OS）。
收集了在凯克医疗中心、洛杉矶县和南加州大学（LAC+USC）医疗中心诊断出的173例III期非IBC患者和17例IBC患者的数据。Cox比例风险回归评估了对EFS和OS有显著意义的变量之间的关联。
多因素分析显示，雌激素受体（ER）阴性状态[风险比（HR）=1.88，95%置信区间（CI）=1.11 - 3.18，p<0.06]和未接受术后放疗（HR=2.07，95%CI=1.03 - 4.15，p<0.04）对较差的EFS有显著影响。高斯卡夫-布鲁姆-理查森（SBR）评分（HR=2.24，95%CI=0.79 - 6.36，p<0.13）和未对乳房进行术后放疗（HR=4.39，95%CI=0.39 - 49.55，p<0.23）与较低的OS率相关。
IBC的诊断预后明显更差。接受乳房切除术后放疗是EFS和OS改善的显著预测因素。
