一种预测结直肠癌根治术后骨转移发生的评分系统。
A Scoring System to Predict the Development of Bone Metastasis After Radical Resection of Colorectal Cancer.
作者信息
Li Ang, Käsmann Lukas, Rades Dirk, Fu Chuangang
机构信息
Department of Colorectal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, P.R. China.
Department of Colorectal Surgery, Shanghai East Hospital, Tongji University, Shanghai, P.R. China.
出版信息
Anticancer Res. 2017 Sep;37(9):5169-5172. doi: 10.21873/anticanres.11938.
BACKGROUND/AIM: To develop a scoring system to predict bone metastasis after radical resection within 5 years.
PATIENTS AND METHODS
We evaluated the patient records of 1,749 patients, of whom 50 patients developed bone metastasis. Treatment-related factors (age, gender, localization, histology, preoperative carbohydrate antigen 199 level, T-stage, lymph node metastasis (LN) and pulmonary metastasis (PM)) were analyzed.
RESULTS
We found three independent risk factors, namely rectal cancer (p=0.038), LN (p=0.006) and metachronous PM (p<0.001). Scoring was conducted by adding zero or one point from each variable and resulted in four groups of 0, 1, 2 or 3 points. Three groups were formed, with 0-1 points vs. 2 points vs. 3 points (1.5% vs. 6.6% and 10.5%, p<0.001).
CONCLUSION
This new score can help clinicians identify patients at risk for continuous monitoring and optimize surveillance to be able to detect and treat bone metastases very early in order to avoid skeletal complications.
背景/目的：开发一种评分系统，以预测根治性切除术后5年内发生骨转移的情况。
患者与方法
我们评估了1749例患者的病历，其中50例发生了骨转移。分析了与治疗相关的因素（年龄、性别、肿瘤位置、组织学类型、术前糖类抗原199水平、T分期、淋巴结转移（LN）和肺转移（PM））。
结果
我们发现了三个独立的危险因素，即直肠癌（p=0.038）、LN（p=0.006）和异时性PM（p<0.001）。通过为每个变量加0分或1分进行评分，结果分为0、1、2或3分的四组。形成了三组，分别为0 - 1分、2分和3分（1.5%对6.6%和10.5%，p<0.001）。
结论
这种新的评分系统可以帮助临床医生识别有风险的患者，以便进行持续监测，并优化监测方案，从而能够在骨转移的极早期进行检测和治疗，以避免骨骼并发症。
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